Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia Journal Article
| Authors: | Pabst, T.; Stillner, E.; Neuberg, D.; Nimer, S.; Willman, C. L.; List, A. F.; Melo, J. V.; Tenen, D. G.; Mueller, B. U. |
| Article Title: | Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia |
| Abstract: | The transcription factor CEBPA is crucial for normal myeloid differentiation. CEBPA gene mutations have been reported in patients with acute myeloid leukaemia. The inevitable evolution of chronic myeloid leukaemia (CML) in chronic phase (CP) to a fatal blast crisis (BC) is assumed to result from the acquisition of additional genetic changes in the leukaemic clone. Gain of CEBPA mutations might represent a key event causing the differentiation block observed in myeloid CML-BC, but not in CML-CP. Here, no CEBPA mutation in 95 CML-BC patients was found, suggesting a limited role, if any, of CEBPA mutations in this disorder. © 2006 Blackwell Publishing Ltd. |
| Keywords: | controlled study; gene mutation; human cell; mutation; transcription factor; cell differentiation; cell line, tumor; chronic myeloid leukemia; disease progression; screening test; genetic screening; granulocyte; differentiation; blast cell crisis; phase transition; blast crisis; ccaat enhancer binding protein alpha; leukemia, myeloid, chronic; cebpa; chronic myeloid leukaemia; ccaat-enhancer-binding protein-alpha |
| Journal Title: | British Journal of Haematology |
| Volume: | 133 |
| Issue: | 4 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2006-05-01 |
| Start Page: | 400 |
| End Page: | 402 |
| Language: | English |
| DOI: | 10.1111/j.1365-2141.2006.06057.x |
| PUBMED: | 16643447 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 4 June 2012" - "CODEN: BJHEA" - "Source: Scopus" |
