Is cancer a disease of self-seeding? Journal Article
| Authors: | Norton, L.; Massague, J. |
| Article Title: | Is cancer a disease of self-seeding? |
| Abstract: | The high cell density, rapid growth rate and large population size of cancer are conventionally attributed to a pathologically high ratio of cell production to cell death. Yet these features might also or instead result from inappropriate cell movement, already understood to underlie invasion and metastasis. This integrating concept could induce a broadening of our existing anticancer pharmacopoeia, which, with mitosis as its predominant target, is now seldom curative. © 2006 Nature Publishing Group. |
| Keywords: | review; cancer growth; neoplasms; cell proliferation; mitosis; animals; cell death; metastasis; models, biological; cell motion; cancer invasion; cancer infiltration; cancer size; carcinoma; medical literature; cell density; growth rate; neoplasm seeding; cancer self seeding |
| Journal Title: | Nature Medicine |
| Volume: | 12 |
| Issue: | 8 |
| ISSN: | 1078-8956 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2006-08-01 |
| Start Page: | 875 |
| End Page: | 878 |
| Language: | English |
| DOI: | 10.1038/nm0806-875 |
| PUBMED: | 16892025 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 111" - "Export Date: 4 June 2012" - "CODEN: NAMEF" - "Source: Scopus" |
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