Response to chemotherapy of a radiation-induced glioblastoma multiforme Journal Article
| Authors: | Nicolardi, L.; Deangelis, L. M. |
| Article Title: | Response to chemotherapy of a radiation-induced glioblastoma multiforme |
| Abstract: | Background: Radiation-induced glioblastoma multiforme (GBM) is particularly resistant to treatment and therapeutic options are limited. We report a patient with a radiation-induced GBM who had a complete response to carmustine and survived for 44 months. Patients and Methods: Case report of a 38-year-old man with a radiation-induced GBM that responded to carmustine. Results: Our patient developed a left occipital GBM 35 years after a left cerebellar astrocytoma was treated with surgery and radiation therapy (4500 rad). The GBM was treated with subtotal resection followed by four cycles of carmustine; a complete response was achieved. He relapsed 34 months after diagnosis and with further surgery survived 44 months from his diagnosis of GBM. Conclusion: GBMs may be a late complication of radiation treatment for pediatric brain tumors. If further radiotherapy is not a therapeutic option, chemotherapy may result in prolonged survival. © Springer Science+Business Media, Inc. 2006. |
| Keywords: | adult; treatment outcome; child, preschool; surgical technique; anamnesis; case report; postoperative period; pathophysiology; radiotherapy, adjuvant; chemotherapy; nuclear magnetic resonance imaging; follow up; brain neoplasms; magnetic resonance imaging; radiotherapy; dexamethasone; carmustine; pneumonia; cause of death; survival time; karnofsky performance status; neoplasms, radiation-induced; contrast enhancement; tumor recurrence; glioblastoma; antineoplastic agents, alkylating; reoperation; craniotomy; neoplasms, second primary; tumor growth; corticosteroid; astrocytoma; treatment withdrawal; brain ventricle peritoneum shunt; neurologic examination; nursing home; brain atrophy; cobalt therapy; brain scintiscanning; radiation-induced glioblastoma; secondary neoplasm |
| Journal Title: | Journal of Neuro-Oncology |
| Volume: | 78 |
| Issue: | 1 |
| ISSN: | 0167-594X |
| Publisher: | Springer |
| Date Published: | 2006-05-01 |
| Start Page: | 55 |
| End Page: | 57 |
| Language: | English |
| DOI: | 10.1007/s11060-005-9053-5 |
| PUBMED: | 16314941 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 4 June 2012" - "CODEN: JNODD" - "Source: Scopus" |
