Use of positron emission tomography to target prostate cancer gene therapy by oncolytic herpes simplex virus Journal Article
| Authors: | Mullerad, M.; Eisenberg, D. P.; Akhurst, T. J.; Adusumilli, P. S.; Riedl, C. C.; Bhargava, A.; Gonen, M.; Finn, R.; Scardino, P. T.; Fong, Y. |
| Article Title: | Use of positron emission tomography to target prostate cancer gene therapy by oncolytic herpes simplex virus |
| Abstract: | Herpes simplex virus (HSV) oncolytic gene therapy is a promising treatment modality against cancer. We have demonstrated that androgen-induced cellular changes enhance oncolytic viral replication and improve efficacy in the treatment of androgen-dependent prostate cancer cell line. Imaging of changes in 2-deoxy-2-[F-18]fluoro-d-glucose (FDG) uptake by positron emission tomography (PET) is a sensitive method of detecting altered cellular metabolism involved in cancer therapy. We therefore hypothesized that FDG-PET can predict tumor response to oncolytic HSV therapy. In this study, androgen increased cell kill (74%) in vitro and enhanced viral yield (2.4-fold) in vivo following HSV therapy. This enhanced efficacy was predicted by high FDG accumulation in intact animals compared to low FDG uptake following orchiectomy (p = 0.002). This proof-of-concept study provides the mechanistic basis for selecting patients for targeted oncolytic viral therapy by means of a noninvasive molecular imaging method in the treatment of prostate cancer. © Academy of Molecular Imaging 2005. |
| Keywords: | controlled study; treatment outcome; treatment response; human cell; genetics; androgen; nonhuman; patient selection; positron emission tomography; antineoplastic agent; radiopharmaceuticals; mouse; animal; animals; mice; image analysis; animal experiment; animal model; in vivo study; cancer cell culture; in vitro study; molecular imaging; cell line, tumor; cancer therapy; prediction; physiology; animalia; prostate cancer; prostatic neoplasms; diagnostic agent; xenograft; nude mouse; mice, nude; prostate tumor; tumor cell line; rat; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; gene therapy; radiopharmaceutical agent; oncolytic virus; herpes virus; simplexvirus; transplantation, heterologous; radiosensitivity; hormonal therapy; virus replication; neoplasm transplantation; orchiectomy; herpes simplex virus; cell metabolism; non invasive measurement; fluorodeoxyglucose; cell killing; cancer transplantation; fluorine radioisotopes; fluorine; viral gene therapy |
| Journal Title: | Molecular Imaging and Biology |
| Volume: | 8 |
| Issue: | 1 |
| ISSN: | 1536-1632 |
| Publisher: | Springer |
| Date Published: | 2006-01-01 |
| Start Page: | 30 |
| End Page: | 35 |
| Language: | English |
| DOI: | 10.1007/s11307-005-0028-x |
| PUBMED: | 16362150 |
| PROVIDER: | scopus |
| PMCID: | PMC1397882 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 4 June 2012" - "CODEN: CPIMF" - "Source: Scopus" |
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