Primary combined-modality therapy for esophageal cancer Journal Article
| Author: | Minsky, B. D. |
| Article Title: | Primary combined-modality therapy for esophageal cancer |
| Abstract: | Based on positive results from the Radiation Therapy Oncology Group (RTOG) 85-01 trial, the conventional nonsurgical treatment of esophageal carcinoma is combined-modality therapy. Dose intensification of the RTOG 85-01 regimen, examined in the Intergroup (INT)-0123/RTOG 94-05 trial, did not improve local control or survival. Areas of clinical investigation include the development of combined-modality therapy regimens with newer systemic agents, the use of 18F-fluorodeoxyglucose positron-emission tomography to assist in the development of innovative radiation treatment planning techniques, and the identification of prognostic molecular markers. The addition of surgery following primary combined-modality therapy apparently does not improve survival, but this finding is controversial. |
| Keywords: | cancer survival; controlled study; treatment outcome; treatment failure; clinical trial; review; squamous cell carcinoma; carcinoma, squamous cell; bevacizumab; cisplatin; fluorouracil; multimodality cancer therapy; antineoplastic agents; paclitaxel; chemotherapy, adjuvant; combined modality therapy; cancer staging; positron emission tomography; methodology; antineoplastic agent; adenocarcinoma; computer assisted tomography; controlled clinical trial; etoposide; esophagitis; randomized controlled trial; combination chemotherapy; algorithms; cetuximab; docetaxel; irinotecan; dysphagia; patient care; disease severity; algorithm; randomized controlled trials; radiation dose fractionation; folinic acid; adjuvant chemotherapy; brachytherapy; intermethod comparison; external beam radiotherapy; cancer control; fractionation; trastuzumab; dose fractionation; oxaliplatin; lethargy; esophagus carcinoma; deglutition disorders; esophagus tumor; esophageal neoplasms; tracheoesophageal fistula |
| Journal Title: | Oncology (Norwalk) |
| Volume: | 20 |
| Issue: | 5 |
| ISSN: | 0890-9091 |
| Publisher: | C M P Medica LLC * The Oncology Group |
| Date Published: | 2006-04-01 |
| Start Page: | 497 |
| End Page: | 505 |
| Language: | English |
| PUBMED: | 16739747 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 4 June 2012" - "CODEN: OCLGE" - "Source: Scopus" |
