Cutting edge: CD28 controls dominant regulatory T cell activity during active immunization Journal Article

Authors: Lyddane, C.; Gajewska, B. U.; Santos, E.; King, P. D.; Furtado, G. C.; Sadelain, M.
Article Title: Cutting edge: CD28 controls dominant regulatory T cell activity during active immunization
Abstract: Ligation of CD28 during Ag recognition plays an important role in the generation of effective T cell responses. However, its peripheral control of regulatory T cell function remains obscure. In this study, we show that naive wild-type or CD28-/- CD4+CD25- T cells exposed to peptide in vivo develop regulatory activity that suppresses the response of adoptively transferred naive T cells to a subsequent immunogenic challenge. We find that although CD28 is engaged during the initial peptide-priming event and is essential to sustain T cell survival, it is not sufficient to prevent the dominance of regulatory T cell function. Immunization with adjuvant abrogates regulatory dominance, reducing overall Foxp3 expression in a CD28-dependent manner. We conclude that CD28 licenses active immunization by regulating Ag-induced immunoregulation. Copyright © 2006 by The American Association of Immunologists, Inc.
Keywords: signal transduction; controlled study; protein expression; unclassified drug; nonhuman; transcription factor foxp3; forkhead transcription factors; animal cell; mouse; animal; metabolism; animals; mice; cell survival; animal experiment; in vivo study; peptide; mice, inbred balb c; immunoregulation; regulatory t lymphocyte; immunology; bagg albino mouse; t-lymphocytes, regulatory; immunogenicity; antigen recognition; cd4+ t lymphocyte; vaccination; adoptive transfer; lipopolysaccharide; cd4 antigen; cd25+ t lymphocyte; forkhead transcription factor; matrix protein; cd28 antigen; antigens, cd28; foxp3 protein, mouse; lymphocyte function; interleukin 2 receptor alpha; adjuvant; interleukin 2 receptor; receptors, interleukin-2; active immunization; ovalbumin; provocation test; influenza matrix protein derived peptide[58-66]; ovalbumin[323-339]
Journal Title: Journal of Immunology
Volume: 176
Issue: 6
ISSN: 0022-1767
Publisher: The American Association of Immunologists, Inc  
Date Published: 2006-03-15
Start Page: 3306
End Page: 3310
Language: English
PUBMED: 16517696
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 9" - "Export Date: 4 June 2012" - "CODEN: JOIMA" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Elmer B Santos
    25 Santos
  2. Michel W J Sadelain
    543 Sadelain
  3. Clay   Lyddane
    10 Lyddane