Purine analogue-based chemotherapy regimens for second-line therapy in patients with chronic lymphocytic leukemia Journal Article
| Authors: | Lamanna, N.; Weiss, M. A. |
| Article Title: | Purine analogue-based chemotherapy regimens for second-line therapy in patients with chronic lymphocytic leukemia |
| Abstract: | A dramatic change has occurred in the management of chronic lymphocytic leukemia (CLL) over the past 20 years. The use of newer therapies, including the purine analogues, has resulted in higher frequencies of response. Combination therapy with purine analogues, alkylators, and/or monoclonal antibodies represents a promising new approach to the treatment of patients with CLL. The most commonly studied regimens have utilized fludarabine, but severe myelosuppression and immunosuppression of these combinations require close attention to dosing and schedule. Of the purine analogues that show activity in CLL, pentostatin appears to be the least myelosuppressive. These combination strategies are associated with high-quality responses in the majority of patients and may one day lead to improved survival or possibly even a cure for patients with CLL. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | fludarabine; prednisone; clinical trial; neutropenia; review; salvage therapy; doxorubicin; dose response; drug potentiation; chemotherapy; rituximab; cancer staging; drug inhibition; infection; bone marrow suppression; thrombocytopenia; antineoplastic combined chemotherapy protocols; alkylating agent; cyclophosphamide; steroid; vincristine; monoclonal antibody; pneumonia; drug uptake; remission; purine derivative; immune deficiency; chronic lymphatic leukemia; chlorambucil; pentostatin; cladribine; leukemia, lymphocytic, chronic; purine nucleosides |
| Journal Title: | Seminars in Hematology |
| Volume: | 43 |
| Issue: | Suppl.2 |
| ISSN: | 0037-1963 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2006-04-01 |
| Start Page: | S44 |
| End Page: | S49 |
| Language: | English |
| DOI: | 10.1053/j.seminhematol.2005.12.009 |
| PUBMED: | 16549114 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 4 June 2012" - "CODEN: SEHEA" - "Source: Scopus" |
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