How to decrease p27Kip1 levels during tumor development Journal Article
| Author: | Koff, A. |
| Article Title: | How to decrease p27Kip1 levels during tumor development |
| Abstract: | p27Kip1, a cyclin-cdk inhibitor, is a tumor suppressor. An overwhelming amount of data correlate p27 abundance to tumor prognosis in humans. Mouse models have supported the importance of decreasing p27 to tumor incidence. Inactivation of most tumor suppressors occurs at the level of gene mutation or silencing, but p27 is regulated posttranscriptionally, and how its level is reduced in cancer is largely unknown. Reports on a series of allelic mice with p27 mutations affecting different posttranscriptional regulatory pathways are emerging and being used to examine which pathways are necessary for p27 turnover associated with tumor development, with surprising results. |
| Keywords: | protein expression; protein phosphorylation; gene mutation; nonhuman; cancer incidence; protein domain; protein localization; neoplasm; neoplasms; phenotype; animal; metabolism; animals; cell cycle; amino acid substitution; protein degradation; protein metabolism; epidermal growth factor receptor 2; pathology; cancer model; carcinogenesis; gene expression regulation; cancer inhibition; gene expression regulation, neoplastic; correlation analysis; transcription regulation; amino terminal sequence; heterozygosity; cyclin dependent kinase inhibitor 1b; cyclin-dependent kinase inhibitor p27; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; short survey; gene inactivation; gene silencing; tumor growth; protein structure; ubiquitin protein ligase e3; k ras protein; tumor suppressor protein; cyclin a; s-phase kinase-associated proteins; cyclin dependent kinase 2; s phase kinase associated protein |
| Journal Title: | Cancer Cell |
| Volume: | 9 |
| Issue: | 2 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2006-02-01 |
| Start Page: | 75 |
| End Page: | 76 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2006.01.020 |
| PUBMED: | 16473274 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 28" - "Export Date: 4 June 2012" - "CODEN: CCAEC" - "Source: Scopus" |
