Preparing the "soil": The premetastatic niche Journal Article
| Authors: | Kaplan, R. N.; Rafii, S.; Lyden, D. |
| Article Title: | Preparing the "soil": The premetastatic niche |
| Abstract: | Current focus on cancer metastasis has centered on the intrinsic factors regulating the cell autonomous homing of the tumor cells to the metastatic site. Specific up-regulation of fibronectin and clustering of bone marrow-derived cellular infiltrates coexpressing matrix metalloproteinases in distant tissue sites before tumor cell arrival are proving to be indispensable for the initial stages of metastasis. These bone marrow-derived hematopoietic progenitors that express vascular endothelial growth factor receptor 1 mobilize in response to the unique array of growth factors produced by the primary tumor. Their arrival in distant sites represents early changes in the local microenvironment, termed the "premetastatic niche," which dictate the pattern of metastatic spread. Focus on the early cellular and molecular events in cancer dissemination and selectivity will likely lead to new approaches to detect and prevent metastasis at its earliest inception. ©2006 American Association for Cancer Research. |
| Keywords: | protein expression; review; bone metastasis; cancer staging; neoplasms; bone marrow cells; metastasis; models, biological; cell infiltration; tumor volume; endothelium cell; lung metastasis; breast tumor; matrix metalloproteinase; tumor cell; neoplasm metastasis; upregulation; hematopoietic stem cell; tumor growth; vascular endothelial growth factor receptor-1; cell adhesion; chemokines; vasculotropin receptor 1; cell homing; matrix metalloproteinases; fibronectin; genetic regulation; fibronectins |
| Journal Title: | Cancer Research |
| Volume: | 66 |
| Issue: | 23 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2006-12-01 |
| Start Page: | 11089 |
| End Page: | 11093 |
| Language: | English |
| DOI: | 10.1158/0008-5472.can-06-2407 |
| PUBMED: | 17145848 |
| PROVIDER: | scopus |
| PMCID: | PMC2952469 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 137" - "Export Date: 4 June 2012" - "CODEN: CNREA" - "Source: Scopus" |
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