Progression of Pneumocystis jiroveci pneumonia in patients receiving echinocandin therapy Journal Article

  


Authors: Kamboj, M.; Weinstock, D.; Sepkowitz, K. A.
Article Title: Progression of Pneumocystis jiroveci pneumonia in patients receiving echinocandin therapy
Abstract: Echinocandins are a novel class of antifungal drugs that target beta (1, 3)-D-glucan synthesis. Animal studies have shown that these agents have activity against Pneumocystis jiroveci infection; however, clinical data are lacking. We reviewed all cases of proven P. jiroveci pneumonia (PCP) in non-human immunodeficiency virus-infected patients at our hospital over a 5 year period (2001-2005). Two patients received conventional PCP treatment and concomitant use of echinocandins for presumed invasive aspergillus. In both cases, PCP progressed, and the patient died. The use of echinocandins in the prevention or treatment of PCP cannot be recommended without evidence to support their effectiveness.
Keywords: adolescent; adult; treatment failure; disease course; case report; antifungal agent; disease progression; antifungal agents; peptides, cyclic; cyclopeptide; fungal protein; fungal proteins; pneumocystis jiroveci; pneumocystosis; pneumocystis infections; echinocandin b
Journal Title: Clinical Infectious Diseases
Volume: 43
Issue: 9
ISSN: 1058-4838
Publisher: Oxford University Press  
Date Published: 2006-11-01
Start Page: e92
End Page: e94
Language: English
DOI: 10.1086/508282
PUBMED: 17029129
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33750092833&partnerID=40&md5=13d68c7c861636fe4b872eefa1f0b80d
Notes: --- - "Cited By (since 1996): 10" - "Export Date: 4 June 2012" - "Source: Scopus"
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MSK Authors
  1. Kent A Sepkowitz
    272 Sepkowitz
  2. David Weinstock
    39 Weinstock
  3. Mini Kamboj
    158 Kamboj
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