Cognitive function of older patients receiving adjuvant chemotherapy for breast cancer: A pilot prospective longitudinal study Journal Article
| Authors: | Hurria, A.; Rosen, C.; Hudis, C.; Zuckerman, E.; Panageas, K. S.; Lachs, M. S.; Witmer, M.; Van Gorp, W. G.; Fornier, M.; D'Andrea, G.; Moasser, M.; Dang, C.; Van Poznak, C.; Holland, J. |
| Article Title: | Cognitive function of older patients receiving adjuvant chemotherapy for breast cancer: A pilot prospective longitudinal study |
| Abstract: | OBJECTIVES: To report on the longitudinal cognitive functioning of older women receiving adjuvant chemotherapy for breast cancer. DESIGN: Neuropsychological and functional status testing were performed before chemotherapy and 6 months after chemotherapy. SETTING: Cancer center. PARTICIPANTS: Thirty-one patients aged 65 and older with Stage I to III breast cancer. Of the 31 patients enrolled, three refused posttesting, and 28 were evaluable. MEASUREMENTS: The following domains of cognitive function were examined: attention; verbal memory; visual memory; and verbal, spatial, psychomotor, and executive functions. RESULTS: Participants had a mean age of 71 (range 65-84): 39% Stage I, 50% Stage II, and 11% Stage III. The number of scores 2 standard deviations (SDs) below the norm were calculated for each patient before and 6 months after chemotherapy; 14 (50%) had no change, 11 (39%) worsened, and three (11%) improved (P=.05). Seven patients (25%) experienced a decline in cognitive function, defined as a 1-SD decline from pre- to posttesting in two or more neuropsychological domains. Exploratory analyses revealed no significant difference between functional status, comorbidity, and depression scale scores and change in overall quality-of-life scores before and after chemotherapy. CONCLUSION: In this cohort of older women receiving adjuvant chemotherapy, a subset experienced a decline in cognitive function from before chemotherapy to 6 months after chemotherapy. Further prospective study is needed to confirm these observations and to identify the subgroup at special risk. © 2006, The American Geriatrics Society. |
| Keywords: | clinical article; controlled study; treatment outcome; aged; aged, 80 and over; functional assessment; doxorubicin; fluorouracil; antineoplastic agents; paclitaxel; cancer adjuvant therapy; chemotherapy, adjuvant; chemotherapy; methotrexate; follow up; follow-up studies; neoplasm staging; prospective studies; quality of life; breast cancer; cyclophosphamide; age factors; breast neoplasms; depression; pilot projects; comorbidity; neuropsychological test; neuropsychological tests; cognition; rating scale; aging; cognitive defect; verbal memory; trastuzumab; attention; functional status; geriatric assessment; older patient; verbal behavior; cognitive function; visual memory; psychomotor activity; exploratory behavior |
| Journal Title: | Journal of the American Geriatrics Society |
| Volume: | 54 |
| Issue: | 6 |
| ISSN: | 0002-8614 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2006-06-01 |
| Start Page: | 925 |
| End Page: | 931 |
| Language: | English |
| DOI: | 10.1111/j.1532-5415.2006.00732.x |
| PUBMED: | 16776787 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 76" - "Export Date: 4 June 2012" - "CODEN: JAGSA" - "Source: Scopus" |
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