Signaling from Smo to Ci/Gli: Conservation and divergence of Hedgehog pathways from Drosophila to vertebrates Journal Article
| Authors: | Huangfu, D.; Anderson, K. V. |
| Article Title: | Signaling from Smo to Ci/Gli: Conservation and divergence of Hedgehog pathways from Drosophila to vertebrates |
| Abstract: | Although the framework of the Hedgehog (Hh) signaling pathway is evolutionarily conserved, recent studies indicate that fundamental differences exist between Drosophila and vertebrates in the way signals are transduced from the membrane protein Smoothened (Smo) to the Ci/Gli transcription factors. For example, Smo structure and the roles of fused and Suppressor of fused have diverged. Recently, many vertebrate-specific components have been identified that act between Smo and Gli. These include intraflagellar transport proteins, which link vertebrate Hh signaling to cilia. Because abnormal Hh signaling can cause birth defects and cancer, these vertebrate-specific components may have roles in human health. |
| Keywords: | signal transduction; carrier protein; review; nonhuman; protein function; animals; models, biological; sonic hedgehog protein; genetic variability; transcription factor; drosophila; central nervous system; transcription factors; evolution, molecular; vertebrata; gene expression regulation, developmental; eukaryota; intracellular signaling peptides and proteins; oncogene proteins; carrier proteins; membrane protein; trans-activators; health; protein structure; erinaceidae; vertebrate; vertebrates; drosophila proteins; receptors, g-protein-coupled; eukaryotic flagellum; genetic conservation; multigene family; birth defect |
| Journal Title: | Development |
| Volume: | 133 |
| Issue: | 1 |
| ISSN: | 0950-1991 |
| Publisher: | Company of Biologists |
| Date Published: | 2006-01-01 |
| Start Page: | 3 |
| End Page: | 14 |
| Language: | English |
| DOI: | 10.1242/dev.02169 |
| PUBMED: | 16339192 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 202" - "Export Date: 4 June 2012" - "CODEN: DEVPE" - "Source: Scopus" |
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