Pathology of genetically engineered mouse models of pancreatic exocrine cancer: Consensus report and recommendations Journal Article
| Authors: | Hruban, R. H.; Adsay, N. V.; Albores-Saavedra, J.; Anver, M. R.; Biankin, A. V.; Boivin, G. P.; Furth, E. E.; Furukawa, T.; Klein, A.; Klimstra, D. S.; Klöppel, G.; Lauwers, G. Y.; Longnecker, D. S.; Luttges, J.; Maitra, A.; Offerhaus, G. J. A.; Pérez-Gallego, L.; Redston, M.; Tuveson, D. A. |
| Article Title: | Pathology of genetically engineered mouse models of pancreatic exocrine cancer: Consensus report and recommendations |
| Abstract: | Several diverse genetically engineered mouse models of pancreatic exocrine neoplasia have been developed. These mouse models have a spectrum of pathologic changes; however, until now, there has been no uniform nomenclature to characterize these changes. An international workshop, sponsored by The National Cancer Institute and the University of Pennsylvania, was held from December 1 to 3, 2004 with the goal of establishing an internationally accepted uniform nomenclature for the pathology of genetically engineered mouse models of pancreatic exocrine neoplasia. The pancreatic pathology in 12 existing mouse models of pancreatic neoplasia was reviewed at this workshop, and a standardized nomenclature with definitions and associated images was developed. It is our intention that this nomenclature will standardize the reporting of genetically engineered mouse models of pancreatic exocrine neoplasia, that it will facilitate comparisons between genetically engineered mouse models and human pancreatic disease, and that it will be broad enough to accommodate newly emerging mouse models of pancreatic neoplasia. ©2006 American Association for Cancer Research. |
| Keywords: | nonhuman; pancreas cancer; pancreatic neoplasms; mouse; animals; mice; animal model; practice guideline; pathology; standardization; genetic engineering; nomenclature; mouse strain; disease models, animal; pancreas function; pancreas disease; terminology; pancreas, exocrine |
| Journal Title: | Cancer Research |
| Volume: | 66 |
| Issue: | 1 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2006-01-01 |
| Start Page: | 95 |
| End Page: | 106 |
| Language: | English |
| DOI: | 10.1158/0008-5472.can-05-2168 |
| PUBMED: | 16397221 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 115" - "Export Date: 4 June 2012" - "CODEN: CNREA" - "Source: Scopus" |
