A re-staging transurethral resection predicts early progression of superficial bladder cancer Journal Article
| Authors: | Herr, H. W.; Donat, S. M. |
| Article Title: | A re-staging transurethral resection predicts early progression of superficial bladder cancer |
| Abstract: | OBJECTIVE: To determine whether pathology on a re-staging transurethral resection (TUR) predicts the early progression of superficial bladder cancer. PATIENTS AND METHODS: In all, 710 patients presenting with multiple superficial bladder cancers were evaluated by re-staging TUR and followed for 5 years. Tumours were classified by stage as confined to mucosa (Ta) or invading submucosa (T1), and by grade (low- or high-grade). Pathology on re-staging TUR was correlated with the endpoints of tumour recurrence and stage progression. RESULTS: Of the 710 patients, 490 (69%) had a recurrence and 149 (21%) progressed over 5 years. Eighty patients had high-grade invasive (T1G3) cancer on re-staging TUR and 61 (76%) progressed to muscle invasion (median time to progression 15 months), compared with 88 of 630 (14%) who had no evidence of tumour (T0) or other than T1 tumours detected on re-staging TUR. CONCLUSION: A re-staging TUR identifies patients with superficial bladder cancer who are at high risk of early tumour progression. © 2006 BJU International. |
| Keywords: | adult; controlled study; aged; aged, 80 and over; disease-free survival; middle aged; major clinical study; disease course; cancer recurrence; cancer growth; cancer staging; follow-up studies; neoplasm staging; bcg vaccine; neoplasm recurrence, local; risk factors; pathology; bladder cancer; prediction; urinary bladder neoplasms; high risk patient; risk assessment; correlation analysis; disease progression; cystectomy; reoperation; progression; transurethral resection; urethra; muscle metastasis; bladder mucosa; submucosa; superficial cancer; re-staging transurethral resection; superficial bladder tumour |
| Journal Title: | BJU International |
| Volume: | 97 |
| Issue: | 6 |
| ISSN: | 1464-4096 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2006-06-01 |
| Start Page: | 1194 |
| End Page: | 1198 |
| Language: | English |
| DOI: | 10.1111/j.1464-410X.2006.06145.x |
| PUBMED: | 16566813 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 42" - "Export Date: 4 June 2012" - "CODEN: BJINF" - "Source: Scopus" |
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