ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes Journal Article
| Authors: | Guillem, J. G.; Wood, W. C.; Moley, J. F.; Berchuck, A.; Karlan, B. Y.; Mutch, D. G.; Gagel, R. F.; Weitzel, J.; Morrow, M.; Weber, B. L.; Giardiello, F.; Rodriguez-Bigas, M. A.; Church, J.; Gruber, S.; Offit, K. |
| Article Title: | ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes |
| Abstract: | Background: A significant portion of cancers are accounted for by a heritable component, which has increasingly been linked to mutations in specific genes. Clinical interventions have been formulated for mutation carriers within affected families. The primary interventions for mutation carriers of highly penetrant syndromes are surgical. Methods: The American Society of Clinical Oncology and the Society of Surgical Oncology formed a task force charged with presenting an educational symposium on surgical management of hereditary cancer syndromes at annual society meetings, and this resulted in a position paper on this topic. The content of both the symposium and the position paper was developed as a consensus statement. Results: This article addresses hereditary breast, colorectal, ovarian/endometrial, and multiple endocrine neoplasias. A brief introduction on the genetics and natural history of each disease is provided, followed by detailed descriptions of modern surgical approaches, clinical and genetic indications, timing of prophylactic surgery, and the efficacy of surgery (when known). Although several recent reviews have addressed the role of genetic testing for cancer susceptibility, this article focuses on the issues surrounding surgical technique, timing, and indications for surgical prophylaxis. Conclusions: Risk-reducing surgical treatment of hereditary cancer is a complex undertaking. It requires a clear understanding of the natural history of the disease, realistic appreciation of the potential benefits and risks of these procedures in potentially otherwise healthy individuals, and the long-term sequelae of such interventions, as well as the individual patient's and family's perceptions of surgical risk and anticipated benefit. Published by Springer Science+Business Media, Inc. © 2006 The Society of Surgical Oncology, Inc. |
| Keywords: | treatment outcome; cancer surgery; surgical technique; gene mutation; mutation; cancer risk; united states; conference paper; endometrium cancer; salpingooophorectomy; genetic analysis; neoplasms; colorectal cancer; treatment indication; genetic predisposition to disease; consensus; ovary cancer; breast cancer; surgical approach; risk assessment; risk; societies, medical; prophylaxis; medical society; medical oncology; thyroidectomy; colorectal surgery; familial cancer; proctocolectomy; risk reduction; hnpcc; adenomatous polyp; desmoid tumor; thyroid medullary carcinoma; neoplastic syndromes, hereditary; familial adenomatous polyposis; genotype phenotype correlation; ileorectal anastomosis; total colon resection; oncogene ret; multiple endocrine neoplasia; hereditary cancer; risk-reducing surgery; surgical prophylaxis |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 13 |
| Issue: | 10 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2006-10-01 |
| Start Page: | 1296 |
| End Page: | 1321 |
| Language: | English |
| DOI: | 10.1245/s10434-006-9036-6 |
| PUBMED: | 16990987 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 4 June 2012" - "CODEN: ASONF" - "Source: Scopus" |
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