Nucleophosmin and cancer Journal Article
| Authors: | Grisendi, S.; Mecucci, C.; Falini, B.; Pandolfi, P. P. |
| Article Title: | Nucleophosmin and cancer |
| Abstract: | NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed, mutated, rearranged and deleted in human cancer. Traditionally regarded as a tumour marker and a putative proto-oncogene, it has now also been attributed with tumour-suppressor functions. Therefore, NPM can contribute to oncogenesis through many mechanisms. The aim of this review is to analyse the role of NPM in cancer, and examine how deregulated NPM activity (either gain or loss of function) can contribute to tumorigenesis. © 2006 Nature Publishing Group. |
| Keywords: | acute granulocytic leukemia; gene mutation; gene deletion; mutation; review; nonhuman; solid tumor; neoplasms; cell proliferation; animals; gene; dna repair; gene overexpression; proto oncogene; unindexed drug; apoptosis; caspase; protein p53; tumor marker; carcinogenesis; cell transformation, neoplastic; nuclear proteins; cancer genetics; tumor suppressor gene; hematologic malignancy; myelodysplastic syndrome; dna; hybrid protein; messenger rna; polo like kinase 1; genomic instability; promyelocytic leukemia; chromosome translocation; large cell lymphoma; arf protein; cycline; ribosome rna; cyclin a; hypoxia inducible factor 1alpha; rna polymerase ii; short hairpin rna; microtubule organizing center; cyclin e; protein mdm2; dna directed rna polymerase; deoxyribonuclease; centrosome; anaplastic lymphoma kinase; cyclin dependent kinase 2; retinoic acid receptor; dna directed dna polymerase alpha; nucleophosmin; ribosome; sumo 1 protein; nerve growth factor; initiation factor 2alpha; internal transcribed spacer; protein kinase r; small nucleolar ribonucleoprotein; npm1 gene |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 6 |
| Issue: | 7 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2006-07-01 |
| Start Page: | 493 |
| End Page: | 505 |
| Language: | English |
| DOI: | 10.1038/nrc1885 |
| PUBMED: | 16794633 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 255" - "Export Date: 4 June 2012" - "CODEN: NRCAC" - "Source: Scopus" |
