Breast cancer susceptibility testing: Past, present and future Journal Article
| Authors: | Goldberg, J. I.; Borgen, P. I. |
| Article Title: | Breast cancer susceptibility testing: Past, present and future |
| Abstract: | Breast cancer is a genetic disease. The cancer phenotype is defined by a complex interplay between oncogenes, tumor-suppressor genes and epigenetic factors. Only 5-10% of all breast cancers can be attributed to one of several breast cancer familial syndromes, the most common of which is the hereditary breast and ovarian syndrome caused by deleterious mutations of the BRCA1 BRCA2 functions of the BRCA proteins are not fully understood, although it is clear that they play a role in the control of transcription, regulation of the cell cycle and management of DNA damage. The inheritance of a deleterious mutation is accompanied by a 50-80% risk of developing breast cancer, 60% risk of developing a contralateral breast cancer and 15-25% risk of developing ovarian cancer. The clinical management of heterozygotes involves several strategies of primary, secondary and tertiary prevention. These include risk-reducing surgery, chemoprevention, lifestyle changes and increased surveillance. As we move beyond the 10-year anniversary of the discovery of the genes, we are inevitably led to thoughtful reflection on the impact of these genes in regards to the greater problem of sporadic breast cancer. © 2006 Future Drugs Ltd. |
| Keywords: | oncoprotein; gene mutation; mutation; review; cancer recurrence; cancer risk; nuclear magnetic resonance imaging; salpingooophorectomy; ovarian neoplasms; phenotype; dna damage; cell cycle; cancer susceptibility; heredity; genetic predisposition to disease; ovary cancer; breast cancer; mastectomy; health survey; gene function; genetic transcription; breast neoplasms; brca1 protein; brca2 protein; heterozygote; dna; mammography; epigenetics; heterozygosity; family history; gene identification; echography; tamoxifen; estrogen receptor; progesterone receptor; risk reduction; tumor suppressor protein; genetic screening; breast carcinogenesis; primary prevention; secondary prevention; lifestyle; genetic regulation; inheritance; tumor-suppressor genes; brca genes; hereditary breast cancer; hereditary ovarian cancer |
| Journal Title: | Expert Review of Anticancer Therapy |
| Volume: | 6 |
| Issue: | 8 |
| ISSN: | 1473-7140 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2006-08-01 |
| Start Page: | 1205 |
| End Page: | 1214 |
| Language: | English |
| DOI: | 10.1586/14737140.6.8.1205 |
| PUBMED: | 16925486 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 14" - "Export Date: 4 June 2012" - "CODEN: ERATB" - "Source: Scopus" |
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