Use of an absorbable membrane to position biologically inductive materials in the periprosthetic space of cemented joints Journal Article


Authors: DiResta, G. R.; Brown, H.; Aiken, S.; Doty, S.; Schneider, R.; Wright, T.; Healey, J. H.
Article Title: Use of an absorbable membrane to position biologically inductive materials in the periprosthetic space of cemented joints
Abstract: A device is presented that positions ultrahigh molecular weight polyethylene (UHMWPE) debris against periprosthetic bone surfaces. This can facilitate the study of aseptic loosening associated with cemented joint prostheses by speeding the appearance of this debris within the periprosthetic space. The device, composed of a 100 μm thick bioabsorbable membrane impregnated with 1.4×109 sub-micron particles of UHMWPE debris, is positioned on the endosteum of the bone prior to the insertion of the cemented orthopedic implant. An in vitro pullout study and an in vivo canine pilot study were performed to investigate its potential to accelerate "time to aseptic loosening" of cemented prosthetic joints. Pullout studies characterized the influence of the membrane on initial implant fixation. The tensile stresses (mean±std.dev.) required to withdraw a prosthesis cemented into canine femurs with and without the membrane were 1.15±0.3 and 1.54±0.01 MPa, respectively; these findings were not significantly different (p>0.4). The in vivo pilot study, involving five dogs, was performed to evaluate the efficacy of the debris to accelerate loosening in a canine cemented hip arthroplasty. Aseptic loosening and lameness occurred within 12 months, quicker than the 30 months reported in a retrospective clinical review of canine hip arthroplasty. © 2005 Elsevier Ltd. All rights reserved.
Keywords: implant; joint prosthesis; nonhuman; animal tissue; animal experiment; retrospective study; pilot study; dog; prosthesis; prosthesis loosening; orthopedics; membranes, artificial; prosthesis failure; equipment failure analysis; membrane; absorption; cementation; materials testing; bone cements; canine; biological membranes; asepsis; tensile strength; animal lameness; polyethylene; aseptic loosening; bioabsorbable membrane; hip replacement; pmma bone cement; uhmwpe debris; tensile stress; joints (anatomy); ultra high molecular weight polyethylene; hip arthroplasty; joint surgery; materials; absorbable implants; polyethylenes
Journal Title: Journal of Biomechanics
Volume: 39
Issue: 5
ISSN: 0021-9290
Publisher: Elsevier Inc.  
Date Published: 2006-01-01
Start Page: 833
End Page: 843
Language: English
DOI: 10.1016/j.jbiomech.2005.02.004
PUBMED: 16488222
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 4 June 2012" - "CODEN: JBMCB" - "Source: Scopus"
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MSK Authors
  1. Holly K Brown
    5 Brown
  2. Sean W Aiken
    2 Aiken
  3. John H Healey
    470 Healey