| Abstract: |
INTRODUCTION: Human bronchioloalveolar carcinoma (BAC) is a disease with an evolving definition. "Pure" BAC, characterized by a bronchioloalveolar growth pattern and no evidence of stromal, vascular, or pleural invasion, represents only 2 to 6% of non-small cell lung cancer (NSCLC) cases, but up to 20% of NSCLC cases may contain elements of BAC. This imprecise definition makes it difficult to perform epidemiologic analyses or to generate accurate animal models. However, because BAC appears to behave clinically differently from adenocarcinoma, a better understanding of this disease entity is imperative. METHODS/RESULTS: At the BAC Consensus Conference in 2004, our committee discussed issues relevant to BAC epidemiology, pathogenesis, and preclinical models. CONCLUSIONS: Elucidation of molecular events involved in BAC tumorigenesis will allow for more precise epidemiologic studies and improved animal models, which will enable development of more effective treatments against the disease. © 2006International Association for the Study of Lung Cancer. |
| Keywords: |
immunohistochemistry; signal transduction; gene mutation; histopathology; pathogenesis; erlotinib; cancer risk; nonhuman; conference paper; pathophysiology; cancer staging; neoplasm staging; sensitivity analysis; adenocarcinoma; mouse; animal; animals; mice; cancer susceptibility; gene expression; diagnosis, differential; lung neoplasms; differential diagnosis; incidence; prevalence; lung cancer; smoking; pathology; enzyme activity; risk factor; histology; risk assessment; carcinogenesis; transgenic mouse; mice, transgenic; disease model; lung tumor; adenoma; genetic engineering; nude mouse; mice, nude; biopsy, needle; heterozygosity; needle biopsy; gefitinib; consensus development; lung alveolus cell carcinoma; dna sequence; cancer epidemiology; epidemiology; disease models, animal; stroma cell; time series analysis; cell interaction; tumor classification; leukocyte; ethnicity; genetic heterogeneity; bronchioloalveolar carcinoma; adenocarcinoma, bronchiolo-alveolar; sheep; preclinical models
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