Chemotherapy resistance in osteosarcoma: Current challenges and future directions Journal Article
| Authors: | Chou, A. J.; Gorlick, R. |
| Article Title: | Chemotherapy resistance in osteosarcoma: Current challenges and future directions |
| Abstract: | For patients with osteosarcoma, the use of chemotherapy has improved survival from 11% with surgical resection alone in the 1960s, to 70% by the mid-1980s. However, survival has since plateaued, despite advances in anticancer therapy. Elucidation of the mechanisms of chemoresistance and implementation of strategies to overcome chemoresistance will likely be pivotal to improving survival. In this review, the focus is on the current understanding of the mechanisms of resistance to the most commonly used agents in the treatment of osteosarcoma and the methods employed to overcome chemotherapy resistance. © 2006 Future Drugs Ltd. |
| Keywords: | osteosarcoma; cancer chemotherapy; cancer survival; bone neoplasms; bone tumor; survival rate; unclassified drug; gene mutation; clinical trial; review; cisplatin; doxorubicin; erlotinib; fluorouracil; cancer combination chemotherapy; drug potentiation; nonhuman; unspecified side effect; antineoplastic agents; pathophysiology; treatment; methotrexate; antineoplastic agent; peginterferon alpha2b; unindexed drug; bone marrow suppression; etoposide; antineoplastic combined chemotherapy protocols; small interfering rna; novel therapies; bisphosphonic acid derivative; cyclophosphamide; vincristine; antineoplastic activity; drug resistance; drug resistance, neoplasm; ifosfamide; cancer resistance; monoclonal antibody; folinic acid; gefitinib; dactinomycin; bleomycin; dna adduct; muramyl tripeptide; phosphatidylethanolamine; pemetrexed; drug delivery system; futurology; glycoprotein p; peginterferon; trimetrexate; bone resection; molecular mechanisms; razoxane; monoclonal antibody 8h9; 17 allylamino 17 demethoxygeldanamycin; chemotherapy resistance; pnu 159548; reolysin; sustained release formulation |
| Journal Title: | Expert Review of Anticancer Therapy |
| Volume: | 6 |
| Issue: | 7 |
| ISSN: | 1473-7140 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2006-07-01 |
| Start Page: | 1075 |
| End Page: | 1085 |
| Language: | English |
| DOI: | 10.1586/14737140.6.7.1075 |
| PUBMED: | 16831079 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 49" - "Export Date: 4 June 2012" - "CODEN: ERATB" - "Source: Scopus" |
