Tumor selectivity of Hsp90 inhibitors: The explanation remains elusive Journal Article
| Authors: | Chiosis, G.; Neckers, L. |
| Article Title: | Tumor selectivity of Hsp90 inhibitors: The explanation remains elusive |
| Abstract: | Two recent papers attempt to solve both the tumor selectivity and the in vivo tumor accumulation profiles seen with some Hsp90 inhibitors. They spotlight the higher affinity of ansamycins' hydroquinone over the quinone form for Hsp90 and further discuss its possible contribution to ansamycins' tumor selectivity. |
| Keywords: | review; antineoplastic agents; antineoplastic agent; neoplasm; neoplasms; animal; metabolism; animals; classification; pathology; physiology; drug antagonism; heat shock protein 90; hsp90 heat-shock proteins |
| Journal Title: | ACS Chemical Biology |
| Volume: | 1 |
| Issue: | 5 |
| ISSN: | 1554-8929 |
| Publisher: | American Chemical Society |
| Date Published: | 2006-06-20 |
| Start Page: | 279 |
| End Page: | 284 |
| Language: | English |
| DOI: | 10.1021/cb600224w |
| PUBMED: | 17163756 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 43" - "Export Date: 4 June 2012" - "Source: Scopus" |
