Heat shock protein-90 inhibitors: A chronicle from geldanamycin to today's agents Journal Article
| Authors: | Chiosis, G.; Lopes, E. C.; Solit, D. |
| Article Title: | Heat shock protein-90 inhibitors: A chronicle from geldanamycin to today's agents |
| Abstract: | Heat shock protein (Hsp)90 is a chaperone with essential roles in maintaining transformation and in elevating the survival and growth potential of cancer cells. The recognition of Hsp90 as an important target in cancer therapy has prompted the identification, development and clinical translation of a large array of Hsp90 inhibitors. This review discusses the modalities that may interfere with this chaperone's function and describes the status of existing and emerging Hsp90 inhibitor classes. © The Thomson Corporation. |
| Keywords: | unclassified drug; histone deacetylase inhibitor; clinical trial; review; gastrointestinal hemorrhage; nonhuman; antineoplastic agents; drug targeting; protein conformation; protein function; neoplasms; mouse; animals; cell survival; unindexed drug; liver toxicity; breast cancer; cell growth; carboxy terminal sequence; protein binding; weight reduction; cancer cell culture; drug structure; tumor xenograft; structure activity relation; pyrimidines; monoclonal antibody; antibodies, monoclonal; amino terminal sequence; drug mechanism; cell transformation; pyrazole derivative; pyrazoles; cancer cell; heat shock protein 90 inhibitor; heat shock protein 90; hsp90 heat-shock proteins; quinones; malignant neoplastic disease; liver disease; molecular structure; purine derivative; protein-tyrosine kinases; adenosine triphosphate; pyrimidine derivative; triazoles; benzimidazole derivative; benzoquinones; lactams, macrocyclic; 4 [n (2 hydroxyethyl) n [2 (3 indolyl)ethyl]aminomethyl]cinnamohydroxamic acid; acetylation; growth inhibition; geldanamycin; radicicol; cycloproparadicicol; pochonin d; hsp90; binding, competitive; pyrazolopyrimidine derivative; ansamycins; ansamycin derivative; g 3130; novobiocin; coumarin derivative; cnf 1010; mycograb; 17 allylamino 17 demethoxygeldanamycin; fr 901228; lbh 589; ver 49009; resorcinol derivative; kos 953; anticancer therapeutics; pu-class hsp90 inhibitors; radicicol and derivatives; 17 dimethyllamino 17 demethoxygeldanamycin; kf 55823; pu 24 fci; pyrrolopyrimidine derivative; zeranol |
| Journal Title: | Current Opinion in Investigational Drugs |
| Volume: | 7 |
| Issue: | 6 |
| ISSN: | 1472-4472 |
| Publisher: | Current Drugs Ltd |
| Date Published: | 2006-06-01 |
| Start Page: | 534 |
| End Page: | 541 |
| Language: | English |
| PUBMED: | 16784024 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 50" - "Export Date: 4 June 2012" - "CODEN: CIDRE" - "Source: Scopus" |
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