Synthesis of Hsp90 dimerization modulators Journal Article

  


Authors: Chiosis, G.; Aguirre, J.; Nicchitta, C. V.
Article Title: Synthesis of Hsp90 dimerization modulators
Abstract: The synthesis and evaluation of several chemical modulators of heat shock protein 90 (Hsp90) dimerization is presented. These agents may represent useful tools to study the importance of N-terminal dimerization and also to determine subunit interface(s) in Hsp90. © 2006 Elsevier Ltd. All rights reserved.
Keywords: signal transduction; drug activity; binding affinity; protein conformation; protein binding; drug structure; drug effect; drug synthesis; structure activity relation; structure-activity relationship; chemistry; amino terminal sequence; heat shock protein 90; quinone derivative; hsp90 heat-shock proteins; quinones; dimerization; chemical structure; molecular structure; protein structure; drug binding; synthesis; binding competition; benzoquinones; lactams, macrocyclic; stereoisomerism; geldanamycin; hsp90; benzoquinone derivative; macrocyclic lactam; binding, competitive; chemical modulator of dimerization; michael addition
Journal Title: Bioorganic & Medicinal Chemistry Letters
Volume: 16
Issue: 13
ISSN: 0960-894X
Publisher: Pergamon-Elsevier Science Ltd  
Date Published: 2006-07-01
Start Page: 3529
End Page: 3532
Language: English
DOI: 10.1016/j.bmcl.2006.03.092
PUBMED: 16621545
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33744477399&partnerID=40&md5=c2fc0b22ee1ff7548ee307439b03e266
Notes: --- - "Cited By (since 1996): 8" - "Export Date: 4 June 2012" - "CODEN: BMCLE" - "Source: Scopus"
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MSK Authors
  1. Gabriela Chiosis
    279 Chiosis
  2. Julia Aguirre
    15 Aguirre
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