Foxg1 is required for proper separation and formation of sensory cristae during inner ear development Journal Article
| Authors: | Chan, H. H.; Simeone, A.; Lai, E.; Wu, D. K. |
| Article Title: | Foxg1 is required for proper separation and formation of sensory cristae during inner ear development |
| Abstract: | The vestibular portion of the inner ear, the three semicircular canals and their sensory cristae, is responsible for detecting angular head movements. It was proposed that sensory cristae induce formation of their non-sensory components, the semicircular canals. Here, we analyzed the inner ears of Foxg1<sup>-/-</sup> mouse mutants, which display vestibular defects that are in conflict with the above model. In Foxg1<sup>-/-</sup> ears, the lateral canal is present without the lateral ampulla, which houses the lateral crista. Our gene expression analyses indicate that at the time when canal specification is thought to occur, the prospective lateral crista is present, which could have induced lateral canal formation prior to its demise. Our genetic fate-mapping analyses indicate an improper separation between anterior and lateral cristae in Foxg1<sup>-/-</sup> mutants. Our data further suggest that a function of Foxg1 in the inner ear is to restrict sensory fate. © 2009 Wiley-Liss, Inc. |
| Keywords: | controlled study; genetics; nonhuman; forkhead transcription factors; mouse; phenotype; mouse mutant; animals; mice; mice, knockout; gene; gene expression; nerve tissue proteins; embryo development; morphogenesis; homeodomain proteins; mice, inbred c57bl; transcription factors; gene expression regulation, developmental; gene mapping; cre; crista; ear; foxg1; otx1; semicircular; septum cruciatum; yfp; bone morphogenetic protein 2; auditory canal; foxg1 gene; inner ear; semicircular canal; vestibular disorder; semicircular ducts |
| Journal Title: | Developmental Dynamics |
| Volume: | 238 |
| Issue: | 11 |
| ISSN: | 1058-8388 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2009-11-01 |
| Start Page: | 2725 |
| End Page: | 2734 |
| Language: | English |
| DOI: | 10.1002/dvdy.22111 |
| PUBMED: | 19842177 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 30 November 2010" - "CODEN: DEDYE" - "Source: Scopus" |
