A novel radiation therapy technique for malignant pleural mesothelioma combining electrons with intensity-modulated photons Journal Article
| Authors: | Chan, M. F.; Chui, C. S.; Song, Y.; Burman, C.; Yorke, E.; Della-Biancia, C.; Rosenzweig, K. E.; Schupak, K. |
| Article Title: | A novel radiation therapy technique for malignant pleural mesothelioma combining electrons with intensity-modulated photons |
| Abstract: | Background and purpose: To investigate the feasibility and potential benefits of combining electron and photon intensity modulated radiotherapy (IMRT) for patients with malignant pleural mesothelioma (MPM). Patients and methods: The planning CT images of 11 MPM patients, six after extrapleural pneumonectomy (EPP) and five after pleurectomy/decortication (P/D), were used for this study. These cases were planned with photon IMRT alone and photon IMRT combined with electrons (IMRT+e). The latter approach incorporated the electron dose into the inverse planning optimization. The resulting doses to the planning target volume (PTV) and relevant critical structures were compared. Results: For all patients, the PTV was well covered and doses to critical structures were clinically acceptable for all patients with both techniques. However, IMRT+e exhibited a distinct advantage in reducing the doses to the liver, ipsilateral kidney, contralateral kidney, and heart (P=0.002, 0.003, 0.025, and 0.001, respectively). Conclusions: This study showed that IMRT or IMRT+e is a viable treatment modality for MPM patients. Both plans can provide excellent target coverage and normal tissue sparing, but with the addition of electron beams, the critical structures can be further spared. Additional refining of the electron contribution is expected to further reduce radiation-induced morbidity. © 2006 Elsevier Ireland Ltd. All rights reserved. |
| Keywords: | clinical article; controlled study; retrospective studies; intensity modulated radiation therapy; postoperative period; treatment planning; cancer radiotherapy; radiation dose; computer assisted tomography; lung resection; pneumonectomy; radiotherapy dosage; radiotherapy; morbidity; radiation injury; algorithms; electron therapy; liver; feasibility study; kidney; imrt; radiotherapy, intensity-modulated; radiation injuries; pleura mesothelioma; mesothelioma; intermethod comparison; radiotherapy planning, computer-assisted; photons; extrapleural pneumonectomy; decortication; pleurectomy; electrons; heart; pleural neoplasms; electron beam; target organ |
| Journal Title: | Radiotherapy and Oncology |
| Volume: | 79 |
| Issue: | 2 |
| ISSN: | 0167-8140 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-05-01 |
| Start Page: | 218 |
| End Page: | 223 |
| Language: | English |
| DOI: | 10.1016/j.radonc.2006.04.007 |
| PUBMED: | 16698098 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 17" - "Export Date: 4 June 2012" - "CODEN: RAOND" - "Source: Scopus" |
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