Aurora kinases: New targets for cancer therapy Journal Article
| Authors: | Carvajal, R. D.; Tse, A.; Schwartz, G. K. |
| Article Title: | Aurora kinases: New targets for cancer therapy |
| Abstract: | The Aurora kinase family is a collection of highly related serine/threonine kinases that functions as a key regulator of mitosis. In mammalian cells, Aurora has evolved into three related kinases known as Aurora-A, Aurora-B, and Aurora-C. These kinases are overexpressed in a number of human cancers, and transfection studies have established Aurora-A as a bone fide oncogene. Because Aurora overexpression is associated with malignancy, these kinases have been targeted for cancer therapy. This article reviews the multiple functions of Aurora kinase in the regulation of mitosis and the mitotic checkpoint, the role of abnormal Aurora kinase activity in the development of cancer, the putative mechanisms of Aurora kinase inhibition and its antitumor effects, the development of the first generation of Aurora kinase inhibitors, and prospects for the future of Aurora kinase inhibition in the treatment of cancer. © 2006 American Association for Cancer Research. |
| Keywords: | protein expression; leukemia; at 9283; aurora kinase inhibitor; cyclopropanecarboxylic acid [4 [4 (4 methyl 1 piperazinyl) 6 (5 methyl 2h pyrazol 3 ylamino) 2 pyrimidinylthio]phenyl]amide; clinical trial; neutropenia; review; advanced cancer; solid tumor; antineoplastic agents; neoplasms; mitosis; animals; enzyme inhibition; anemia; lung non small cell cancer; neuropathy; thrombocytopenia; antineoplastic activity; enzyme activity; chronic myeloid leukemia; cancer therapy; carcinogenesis; protein kinase inhibitors; cancer inhibition; drug mechanism; protein-serine-threonine kinases; enzyme localization; aurora b kinase; aurora a kinase; pha 739358; azd 1152; hesperadin; mln 8054; mp 235; mp 529; n [4 [6 methoxy 7 (3 morpholinopropoxy) 4 quinazolinylamino]phenyl]benzamide; pha 680632; r 763; sns 314 |
| Journal Title: | Clinical Cancer Research |
| Volume: | 12 |
| Issue: | 23 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2006-12-01 |
| Start Page: | 6869 |
| End Page: | 6875 |
| Language: | English |
| DOI: | 10.1158/1078-0432.ccr-06-1405 |
| PUBMED: | 17145803 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 110" - "Export Date: 4 June 2012" - "CODEN: CCREF" - "Source: Scopus" |
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