High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients Journal Article
| Authors: | Carrasco, D. R.; Tonon, G.; Huang, Y.; Zhang, Y.; Sinha, R.; Feng, B.; Stewart, J. P.; Zhan, F.; Khatry, D.; Protopopova, M.; Protopopov, A.; Sukhdeo, K.; Hanamura, I.; Stephens, O.; Barlogie, B.; Anderson, K. C.; Chin, L.; Shaughnessy, J. D. Jr; Brennan, C.; DePinho, R. A. |
| Article Title: | High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients |
| Abstract: | To identify genetic events underlying the genesis and progression of multiple myeloma (MM), we conducted a high-resolution analysis of recurrent copy number alterations (CNAs) and expression profiles in a collection of MM cell lines and outcome-annotated clinical specimens. Attesting to the molecular heterogeneity of MM, unsupervised classification using nonnegative matrix factorization (NMF) designed for array comparative genomic hybridization (aCGH) analysis uncovered distinct genomic subtypes. Additionally, we defined 87 discrete minimal common regions (MCRs) within recurrent and highly focal CNAs. Further integration with expression data generated a refined list of MM gene candidates residing within these MCRs, thereby providing a genomic framework for dissection of disease pathogenesis, improved clinical management, and initiation of targeted drug discovery for specific MM patients. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | treatment outcome; disease-free survival; gene mutation; cancer growth; drug targeting; cancer patient; genetic analysis; multiple myeloma; gene expression profiling; cancer cell culture; drug specificity; carcinogenesis; tissue section; gene expression regulation, neoplastic; gene identification; genomics; cellcycle; gene dosage; cancer classification; chromosomes, human; comparative genomic hybridization; genome, human; diploidy; genetic heterogeneity; chromosome high resolution banding analysis |
| Journal Title: | Cancer Cell |
| Volume: | 9 |
| Issue: | 4 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2006-04-01 |
| Start Page: | 313 |
| End Page: | 325 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2006.03.019 |
| PUBMED: | 16616336 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 167" - "Export Date: 4 June 2012" - "CODEN: CCAEC" - "Source: Scopus" |
