Malignant melanoma metastatic to a basal cell carcinoma simulating the pattern of a basomelanocytic tumor Journal Article
| Authors: | Busam, K. J.; Halpern, A.; Marghoob, A. A. |
| Article Title: | Malignant melanoma metastatic to a basal cell carcinoma simulating the pattern of a basomelanocytic tumor |
| Abstract: | We report a case of metastatic melanoma colliding with and colonizing a basal cell carcinoma (BCC) on the head of a 69-year-old man. The man had a prior history of multiple primary BCCs and melanomas. One of his primary melanomas, on the left scalp, recurred locally and resulted in the development of numerous in-transit metastases. A bluish nodule was noted on the postauricular area with clinical features consistent with a pigmented BCC. Dermoscopy showed some large gray-blue ovoid structures and blood vessels, features also consistent with BCC. However, the histologic features revealed that the nodule consisted of both metastatic melanoma as well as BCC. Melanoma was present adjacent to as well as within the epithelium of the BCC. The intimate association of melanoma cells within the nodules of BCC simulated the pattern of so-called "malignant basomelanocytic tumor," a recently proposed novel entity. To our knowledge, this is the first description of metastatic melanoma colonizing a BCC. Copyright © 2005 by Lippincott Williams & Wilkins. |
| Keywords: | immunohistochemistry; aged; histopathology; case report; metabolism; melanoma; neoplasm recurrence, local; basal cell carcinoma; skin biopsy; skin neoplasms; malignant lentigo; diagnosis, differential; tumor volume; differential diagnosis; pathology; epiluminescence microscopy; cancer invasion; skin tumor; tumor recurrence; epithelium cell; malignant neoplastic disease; carcinoma, basal cell; multiple cancer; neoplasms, multiple primary; skin metastasis; basaomelanocytic tumor |
| Journal Title: | American Journal of Surgical Pathology |
| Volume: | 30 |
| Issue: | 1 |
| ISSN: | 0147-5185 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2006-01-01 |
| Start Page: | 133 |
| End Page: | 136 |
| Language: | English |
| DOI: | 10.1097/01.pas.0000179118.76904.02 |
| PUBMED: | 16330954 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 4 June 2012" - "CODEN: AJSPD" - "Source: Scopus" |
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