Inadvertent use of aromatase inhibitors in patients with breast cancer with residual ovarian function: Cases and lessons Journal Article
| Authors: | Burstein, H. J.; Mayer, E.; Partridge, A. H.; O'Kane, H.; Litsas, G.; Come, S. E.; Hudis, C. A.; Goldstein, D. F.; Muss, H. B.; Winer, E. P.; Garber, J. E. |
| Article Title: | Inadvertent use of aromatase inhibitors in patients with breast cancer with residual ovarian function: Cases and lessons |
| Abstract: | Aromatase inhibitors (AIs) are important adlunctive therapy for postmenopausal women with hormone receptor-positive, early-stage breast cancer. At the present time, AIs have no role for the management of breast cancer in premenopausal women. We report on several cases of the inadvertent use of AI therapy among women with residual ovarian function. A common experience in these cases was the onset of chemotherapy-related amenorrhea before initiation of AI therapy, which confounded assessment of true menopausal status. We believe clinicians should be aware of the potential ovarian reserve among women with treatment-related amenorrhea so as to avoid use of AI therapy in patients in whom there is uncertainty about menopausal status. |
| Keywords: | adult; clinical article; middle aged; doxorubicin; fluorouracil; antineoplastic agents; paclitaxel; cancer adjuvant therapy; cancer patient; cancer staging; salpingooophorectomy; carboplatin; ovary cancer; breast cancer; ovariectomy; aromatase inhibitor; estrogen; cyclophosphamide; breast neoplasms; medical assessment; gonadorelin; time; docetaxel; exemestane; leuprorelin; ovary; experience; tamoxifen; epirubicin; letrozole; premenopause; trastuzumab; anastrozole; hormone receptor; menopause; awareness; estradiol; aromatase inhibitors; drug use; follitropin; hormone determination; vagina bleeding; medication errors; amenorrhea; ovary function; menopausal status; menstruation |
| Journal Title: | Clinical Breast Cancer |
| Volume: | 7 |
| Issue: | 2 |
| ISSN: | 1526-8209 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-06-01 |
| Start Page: | 158 |
| End Page: | 161 |
| Language: | English |
| DOI: | 10.3816/CBC.2006.n.026 |
| PUBMED: | 16800976 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 4 June 2012" - "CODEN: CBCLB" - "Source: Scopus" |
