Principal component, Varimax rotation and cost analysis of volume effects in rectal bleeding in patients treated with 3D-CRT for prostate cancer Journal Article

  


Authors: Bauer, J. D.; Jackson, A.; Skwarchuk, M.; Zelefsky, M.
Article Title: Principal component, Varimax rotation and cost analysis of volume effects in rectal bleeding in patients treated with 3D-CRT for prostate cancer
Abstract: We investigate the utility of principal component analysis as a tool for obtaining dose-volume combinations related to rectal bleeding after radiotherapy for prostate cancer. A direct implementation of principal component analysis reduces the number of degrees of freedom from the patient's dose-volume histograms that are associated with bleeding. However, when low-variance principal components are strongly correlated to outcome, their interpretation is problematic. A Varimax rotation is employed to aid in interpretability of the low-variance principal components. This procedure brings us closer to finding unique dose-volume combinations related to outcome but reintroduces correlation, requiring analysis of the overlap of information contained in such modes. Finally, we present examples of cost-benefit analyses for candidate dose-volume constraints for use in treatment planning. © 2006 IOP Publishing Ltd.
Keywords: major clinical study; gastrointestinal hemorrhage; treatment planning; radiation dose; tumor volume; radiotherapy; risk factors; radiation injury; oncology; risk assessment; mathematical model; prostate cancer; prostatic neoplasms; radiation injuries; radiotherapy planning, computer-assisted; radiotherapy, conformal; patient treatment; computer assisted radiotherapy; logistic regression analysis; false positive result; cost benefit analysis; histogram; receiver operating characteristic; rectum; rectum hemorrhage; principal component analysis; covariance; interpretability; dose volume combinations; rectal bleeding; cathode ray tubes; degrees of freedom (mechanics); varimax rotation
Journal Title: Physics in Medicine and Biology
Volume: 51
Issue: 20
ISSN: 0031-9155
Publisher: IOP Publishing Ltd  
Date Published: 2006-10-01
Start Page: 5105
End Page: 5123
Language: English
DOI: 10.1088/0031-9155/51/20/003
PUBMED: 17019028
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33749648136&partnerID=40&md5=c57404269eec0317506898381c0f1fee
Notes: --- - "Cited By (since 1996): 4" - "Export Date: 4 June 2012" - "Article No.: 003" - "CODEN: PHMBA" - "Source: Scopus"
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MSK Authors
  1. Joseph D Bauer
    4 Bauer
  2. Michael J Zelefsky
    754 Zelefsky
  3. Mark Skwarchuk
    10 Skwarchuk
  4. Andrew Jackson
    254 Jackson
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