A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas Journal Article


Authors: Anderson, S. E.; Keohan, M. L.; D'adamo, D. R.; Maki, R. G.
Article Title: A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas
Abstract: Introduction. The role of vinorelbine in specific soft tissue sarcoma subtypes is unclear. We present retrospective single institution experience with single-agent vinorelbine in subjects with metastatic soft tissue malignancies. Methods. Fifty-eight patients were treated with single agent intravenous vinorelbine between April 1997 and December 2004. Doxorubicin had been administered previously to 53 subjects(91%), and the median number of lines of previous chemotherapy was 3 (range 0-7). Results. Patients received a median 6 doses of vinorelbine (range 1-65). The overall response rate was 6% (3 patients: 1 angiosarcoma, 1 epithelioid sarcoma, and 1embryonal rhabdomyosarcoma). Fourteen patients (26%) experienced a best result of stable disease. Median time to progression was 1.8 months (95% confidence intervals1.5-2.1 months, Kaplan-Meier estimate). Eight patients experienced grade 3 or 4 toxicity,most commonly febrile neutropenia. Conclusion. Vinorelbine demonstrates limited activity in a heavily pretreated group of soft-tissue sarcoma patients. Prospective investigation may be considered for selected sarcoma subtypes. Copyright © 2006 Sibyl E. Anderson et al.
Keywords: adult; controlled study; aged; major clinical study; constipation; doxorubicin; cancer growth; dose response; drug dose reduction; side effect; metastasis; mucosa inflammation; dehydration; angiosarcoma; retrospective study; febrile neutropenia; lung embolism; confidence interval; drug fatality; soft tissue sarcoma; nausea and vomiting; kaplan meier method; navelbine; epithelioid sarcoma; embryonal rhabdomyosarcoma; drug extravasation
Journal Title: Sarcoma
Volume: 2006
ISSN: 1357-714X
Publisher: Hindawi Publishing Corporation  
Date Published: 2006-01-01
Start Page: 15947
Language: English
DOI: 10.1155/srcm/2006/15947
PROVIDER: scopus
PMCID: PMC1698137
PUBMED: 17496991
DOI/URL:
Notes: --- - "Article No.: 15947" - "Cited By (since 1996): 7" - "Export Date: 4 June 2012" - "CODEN: SARCF" - "Source: Scopus"
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MSK Authors
  1. David R D'Adamo
    37 D'Adamo
  2. Robert Maki
    211 Maki
  3. Mary Louise Keohan
    65 Keohan