A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas Journal Article
| Authors: | Anderson, S. E.; Keohan, M. L.; D'adamo, D. R.; Maki, R. G. |
| Article Title: | A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas |
| Abstract: | Introduction. The role of vinorelbine in specific soft tissue sarcoma subtypes is unclear. We present retrospective single institution experience with single-agent vinorelbine in subjects with metastatic soft tissue malignancies. Methods. Fifty-eight patients were treated with single agent intravenous vinorelbine between April 1997 and December 2004. Doxorubicin had been administered previously to 53 subjects(91%), and the median number of lines of previous chemotherapy was 3 (range 0-7). Results. Patients received a median 6 doses of vinorelbine (range 1-65). The overall response rate was 6% (3 patients: 1 angiosarcoma, 1 epithelioid sarcoma, and 1embryonal rhabdomyosarcoma). Fourteen patients (26%) experienced a best result of stable disease. Median time to progression was 1.8 months (95% confidence intervals1.5-2.1 months, Kaplan-Meier estimate). Eight patients experienced grade 3 or 4 toxicity,most commonly febrile neutropenia. Conclusion. Vinorelbine demonstrates limited activity in a heavily pretreated group of soft-tissue sarcoma patients. Prospective investigation may be considered for selected sarcoma subtypes. Copyright © 2006 Sibyl E. Anderson et al. |
| Keywords: | adult; controlled study; aged; major clinical study; constipation; doxorubicin; cancer growth; dose response; drug dose reduction; side effect; metastasis; mucosa inflammation; dehydration; angiosarcoma; retrospective study; febrile neutropenia; lung embolism; confidence interval; drug fatality; soft tissue sarcoma; nausea and vomiting; kaplan meier method; navelbine; epithelioid sarcoma; embryonal rhabdomyosarcoma; drug extravasation |
| Journal Title: | Sarcoma |
| Volume: | 2006 |
| ISSN: | 1357-714X |
| Publisher: | Hindawi Publishing Corporation |
| Date Published: | 2006-01-01 |
| Start Page: | 15947 |
| Language: | English |
| DOI: | 10.1155/srcm/2006/15947 |
| PROVIDER: | scopus |
| PMCID: | PMC1698137 |
| PUBMED: | 17496991 |
| DOI/URL: | |
| Notes: | --- - "Article No.: 15947" - "Cited By (since 1996): 7" - "Export Date: 4 June 2012" - "CODEN: SARCF" - "Source: Scopus" |
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