The effect of unrelated donor marrow transplantation on health-related quality of life: A report of the unrelated donor marrow transplantation trial (T-cell depletion trial) Journal Article
| Authors: | Altmaier, E. M.; Ewell, M.; McQuellon, R.; Geller, N.; Carter, S. L.; Henslee-Downey, J.; Davies, S.; Papadopoulos, E.; Yanovich, S.; Gingrich, R. |
| Article Title: | The effect of unrelated donor marrow transplantation on health-related quality of life: A report of the unrelated donor marrow transplantation trial (T-cell depletion trial) |
| Abstract: | The primary objective of this study was to compare health-related quality of life (HRQL) in adult patients undergoing either ex vivo T cell-depleted bone marrow transplantation or conventional marrow transplantation. Data on patients' HRQL were gathered as part of a multicenter randomized trial comparing the effect of ex vivo T-cell depletion versus methotrexate and cyclosporine immunosuppression on disease-free survival. HRQL assessments were conducted at baseline, day +100, 6 months, 1 year, and 3 years. There were no treatment arm differences 1 year after transplantation on the Functional Assessment of Cancer Therapy, Bone Marrow Transplantation, the Medical Outcomes Study Short-Form 36, and the Centers for Epidemiological Studies of Depression. The lack of treatment differences was robust across types of data analyses that took baseline functioning into account and that recognized the sensitivity of outcome measures to assumptions concerning missing data. The trajectory of recovery revealed an initial decrease in function and then a recovery to pretreatment levels that were similar for both treatment arms. Furthermore, the patients in both treatment groups returned to a functional level that approximated general US population norms. Even though the incidence of acute graft-versus-host disease was slightly higher in the conventional treatment arm, T-cell depletion did not differentially affect HRQL at 1 year after transplantation. © 2006 American Society for Blood and Marrow Transplantation. |
| Keywords: | adult; cancer survival; controlled study; treatment outcome; antibiotic agent; functional assessment; human cell; major clinical study; clinical trial; united states; cytarabine; methotrexate; outcome assessment; follow-up studies; sensitivity analysis; t-lymphocytes; quality of life; controlled clinical trial; randomized controlled trial; incidence; cyclophosphamide; cancer therapy; time factors; depression; population research; acute graft versus host disease; donor; tissue donors; health status; multicenter study; data analysis; short form 36; t cell depletion; immunosuppressive treatment; bone marrow transplantation; ex vivo study; convalescence; cyclosporin; immunosuppressive agents; lymphocyte depletion; thymocyte antibody; t-cell depletion; interviews; normal value |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 12 |
| Issue: | 6 |
| ISSN: | 1083-8791 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-06-01 |
| Start Page: | 648 |
| End Page: | 655 |
| Language: | English |
| DOI: | 10.1016/j.bbmt.2006.01.003 |
| PUBMED: | 16737938 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 12" - "Export Date: 4 June 2012" - "CODEN: BBMTF" - "Source: Scopus" |
