Postoperative chemotherapy in nonsmall cell lung cancer: A systematic review Journal Article
| Authors: | Alam, N.; Darling, G.; Shepherd, F. A.; Mackay, J. A.; Evans, W. K. |
| Article Title: | Postoperative chemotherapy in nonsmall cell lung cancer: A systematic review |
| Abstract: | A systematic review of the evidence for postoperative chemotherapy in completely resected nonsmall cell lung cancer was conducted. Seven meta-analyses and 25 randomized trials met the pre-defined eligibility criteria for the review. The evidence indicates that postoperative platinum-based chemotherapy improves survival compared with surgery alone; for patients with a good performance status who are fit enough for chemotherapy, the survival benefits strongly outweigh the adverse effects of treatment. To date the trials restricted to stage IB or II disease have obtained the greatest survival benefits with postoperative platinum-based chemotherapy. The evidence does not support the use of postoperative radiotherapy with chemotherapy. © 2006 The Society of Thoracic Surgeons. |
| Keywords: | survival; cancer survival; survival analysis; cancer surgery; survival rate; clinical trial; mortality; neutropenia; review; postoperative period; cisplatin; doxorubicin; cancer combination chemotherapy; multimodality cancer therapy; risk benefit analysis; unspecified side effect; paclitaxel; cancer adjuvant therapy; cancer radiotherapy; postoperative care; radiation dose; outcome assessment; antineoplastic agent; evidence based medicine; adenocarcinoma; carboplatin; controlled clinical trial; anemia; etoposide; blood toxicity; esophagitis; leukopenia; lung non small cell cancer; randomized controlled trial; carcinoma, non-small-cell lung; lung neoplasms; radiotherapy dosage; alkylating agent; cyclophosphamide; febrile neutropenia; pneumonia; lung tumor; drug fatality; survival time; disease severity; health status; randomized controlled trials; systematic review; intermethod comparison; mitomycin c; vindesine; platinum derivative; randomization; navelbine; mitomycin; lung fibrosis; meta analysis; performance; chemokine receptor; receptors, chemokine; tegafur; meta-analysis; uft; cmklr1 protein, human |
| Journal Title: | Annals of Thoracic Surgery |
| Volume: | 81 |
| Issue: | 5 |
| ISSN: | 0003-4975 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2006-05-01 |
| Start Page: | 1926 |
| End Page: | 1936 |
| Language: | English |
| DOI: | 10.1016/j.athoracsur.2005.04.045 |
| PUBMED: | 16631715 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 13" - "Export Date: 4 June 2012" - "CODEN: ATHSA" - "Source: Scopus" |
