Plerixafor plus granulocyte-colony stimulating factor for autologous hematopoietic stem cell mobilization in patients with metastatic neuroblastoma Journal Article

  

Authors:	Modak, S.; Cheung, I. Y.; Kushner, B. H.; Kramer, K.; Reich, L.; Cheung, N. K. V.
Article Title:	Plerixafor plus granulocyte-colony stimulating factor for autologous hematopoietic stem cell mobilization in patients with metastatic neuroblastoma
Abstract:	Current therapies for high-risk neuroblastoma (NB) necessitate the availability of several aliquots of autologous peripheral blood stem cells to reverse-associated myelosuppression. Priming with the CXCR4 inhibitor plerixafor plus G-CSF was associated with successful stem cell harvest in 5/7 heavily prior-treated patients with stage 4 NB who had previously failed G-CSF priming. Minimal residual disease was not detected in harvested cells from any patient despite the presence of disease in bone/bone marrow in 6/7. Hematopoietic reconstitution was achieved in all three patients receiving plerixafor-primed stem cells after myeloablative therapy. Plerixafor is an effective and safe agent for stem cell collection in patients with NB. © 2011 Wiley Periodicals, Inc.
Keywords:	adolescent; adult; child; clinical article; treatment outcome; child, preschool; retrospective studies; drug efficacy; drug safety; drug therapy, combination; neuroblastoma; stem cell mobilization; granulocyte colony stimulating factor; granulocyte colony-stimulating factor; plerixafor; hematopoietic stem cell mobilization; heterocyclic compounds; autologous hematopoietic stem cell transplantation; receptors, cxcr4
Journal Title:	Pediatric Blood and Cancer
Volume:	58
Issue:	3
ISSN:	1545-5009
Publisher:	Wiley Periodicals, Inc
Date Published:	2012-03-01
Start Page:	469
End Page:	471
Language:	English
DOI:	10.1002/pbc.23132
PUBMED:	21416584
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-80051494958&partnerID=40&md5=ec049dd7010d0135c3ce07a5cde59dc8
Notes:	--- - "Cited By (since 1996): 1" - "Export Date: 7 May 2012" - "CODEN: PBCEA" - "Source: Scopus"

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