Safety and pharmacokinetic trial of docetaxel plus an Astragalus-based herbal formula for non-small cell lung cancer patients Journal Article
| Authors: | Cassileth, B. R.; Rizvi, N.; Deng, G.; Yeung, K. S.; Vickers, A.; Guillen, S.; Woo, D.; Coleton, M.; Kris, M. G. |
| Article Title: | Safety and pharmacokinetic trial of docetaxel plus an Astragalus-based herbal formula for non-small cell lung cancer patients |
| Abstract: | Purpose: To study a commonly used Astragalus-based herbal formula previously found effective in non-small cell lung cancer (NSCLC) on the pharmacokinetics of docetaxel in patients with NSCLC. Methods: Patients with advanced NSCLC who progressed after prior platinum-containing chemotherapy were accrued and received docetaxel at 35 mg/m<sup>2</sup> for 3 weeks followed by 1 week of rest. At 4 days prior to the second dosing, Jinfukang was given orally. Pharmacokinetic studies of initial-dose docetaxel (in the absence of Jinfukang) and the third dose (in the presence of Jinfukang) were compared. Results: Of the 24 patients enrolled, 21 started Jinfukang and docetaxel. Jinfukang had no significant impact on the pharmacokinetics of docetaxel. Median time to progression or withdrawal from treatment was 7 weeks. Twelve patients were removed from study for progression of disease; nine patients withdrew. Conclusions: Jinfukang did not alter the pharmacokinetics of docetaxel nor appear to affect survival in this study. © 2009 Springer-Verlag. |
| Keywords: | adult; cancer survival; clinical article; controlled study; treatment outcome; aged; unclassified drug; clinical trial; disease course; fatigue; advanced cancer; area under the curve; drug safety; drug withdrawal; chemotherapy; controlled clinical trial; lung non small cell cancer; lung cancer; docetaxel; hyperglycemia; lymphocytopenia; chemotherapy induced emesis; drug distribution; drug clearance; nausea and vomiting; plant extract; fruit; botanicals; astragalus; asparagus cochinchinensis extract; astragalus membranaceus extract; cornus officinalis extract; epimedium sagittatum extract; glehnia littoralis extract; gynostemma pentaphyllum extract; jinfukang; ligustrum lucidum extract; ophiopogon japonicus extract; paris polyphylla extract; salvia chinensis extract; selaginella doederleinii extract; trigonella foenum graecum extract; astragalus membranaceus; chinese herb; maximum plasma concentration; plant leaf; plant root; plant seed; time to maximum plasma concentration |
| Journal Title: | Cancer Chemotherapy and Pharmacology |
| Volume: | 65 |
| Issue: | 1 |
| ISSN: | 0344-5704 |
| Publisher: | Springer |
| Date Published: | 2009-12-01 |
| Start Page: | 67 |
| End Page: | 71 |
| Language: | English |
| DOI: | 10.1007/s00280-009-1003-z |
| PROVIDER: | scopus |
| PUBMED: | 19421753 |
| PMCID: | PMC3746541 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 30 November 2010" - "CODEN: CCPHD" - "Source: Scopus" |
