Histopathologic and radiologic assessment of chemotherapeutic response in Ewing's sarcoma: A review Journal Article


Authors: García-Castellano, J. M.; Atallah Yordi, N.; Reyes, C.; Healey, J. H.
Article Title: Histopathologic and radiologic assessment of chemotherapeutic response in Ewing's sarcoma: A review
Abstract: Ewing's sarcoma is a highly malignant tumor that metastasizes rapidly and is thus associated with a low survival rate. The intensification of chemotherapy has been shown to improve the overall survival of patients with Ewing's sarcoma. However, intensified chemotherapy can lead to increased toxicity or even the development of secondary malignancies. The stratification of patients with Ewing's sarcoma into "good" and "poor" responders may help guide the administration of progressively more intensified chemotherapy. Thus, an accurate assessment of the chemotherapeutic response, as well as the extent of chemotherapy-induced tumor necrosis, is critical for avoiding potential treatment-related complications in these patients. This paper reviews the methods currently used to evaluate chemotherapeutic response in Ewing's sarcoma, focusing specifically on histopathologic and imaging analyses, and discusses novel therapies and imaging methods that may help improve the overall survival of these patients. © 2012 José M. Garca-Castellano et al.
Journal Title: Sarcoma
Volume: 2012
ISSN: 1357-714X
Publisher: Hindawi Publishing Corporation  
Date Published: 2012-01-01
Start Page: 357424
Language: English
DOI: 10.1155/2012/357424
PROVIDER: scopus
PMCID: PMC3329737
PUBMED: 22550418
DOI/URL:
Notes: --- - "Export Date: 1 May 2012" - "CODEN: SARCF" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. John H Healey
    387 Healey
  2. Maria Carolina Reyes
    16 Reyes