The use of back-up units to enhance the safety of unrelated donor cord blood transplantation Journal Article
| Authors: | Ponce, D. M.; Lubin, M.; Gonzales, A. M.; Byam, C.; Wells, D.; Ferrante, R.; Heller, G.; Giralt, S.; Papadopoulos, E. B.; Kernan, N. A.; Scaradavou, A.; Barker, J. N. |
| Article Title: | The use of back-up units to enhance the safety of unrelated donor cord blood transplantation |
| Abstract: | The inability to obtain additional stem cells is a disadvantage of unrelated donor cord blood transplantation (CBT). Moreover, in the event of problems with unit shipment, compromised unit quality, thaw mishaps, or graft failure, the time to secure a back-up graft could be unacceptable. Emergent shipment of 1 to 2 back-up units that have been previously typed and reserved could overcome this limitation. However, the advantages of this approach are not established. Therefore, we present our use of back-up units over a 5.5-year period. Six of 121 CBT recipients (5%) required back-up unit infusion. Indications included shipment mishaps (n = 2), poor unit viability (n = 2), significant infusion reaction (n = 1), and graft failure (n = 1). Lack of back-up units would have caused transplantation delay or infusion of inferior-quality units. Five of the 6 patients achieved sustained donor engraftment. We demonstrate that back-up units are emergently required in a significant minority of patients, supporting the incorporation of at least 1 back-up unit in cord blood (CB) selection algorithms to enhance CBT safety. © 2012 American Society for Blood and Marrow Transplantation. |
| Keywords: | graft failure; cord blood transplantation; double unit graft |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 18 |
| Issue: | 4 |
| ISSN: | 1083-8791 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-04-01 |
| Start Page: | 648 |
| End Page: | 651 |
| Language: | English |
| DOI: | 10.1016/j.bbmt.2011.12.588 |
| PROVIDER: | scopus |
| PMCID: | PMC3303962 |
| PUBMED: | 22245598 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 April 2012" - "CODEN: BBMTF" - "Source: Scopus" |
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