Iatrogenic hyperthyroidism does not promote weight loss or prevent ageing-related increases in body mass in thyroid cancer survivors Journal Article
| Authors: | Polotsky, H. N.; Brokhin, M.; Omry, G.; Polotsky, A. J.; Tuttle, R. M. |
| Article Title: | Iatrogenic hyperthyroidism does not promote weight loss or prevent ageing-related increases in body mass in thyroid cancer survivors |
| Abstract: | Context: Thyroid cancer survivors represent a unique population in which the potential long-term effects of brief periods of intentional thyroid hormone withdrawal and/or prolonged periods of iatrogenic hyperthyroidism on body weight and body mass were evaluated. Objectives: The objectives of this study were to characterize body mass changes over several years in a cohort of thyroid cancer patients with iatrogenic hyperthyroidism and to compare these changes with the expected weight gain in age-matched healthy control populations. We also evaluated the possibility that the method of preparation [thyroid hormone withdrawal (THW) vs recombinant human TSH (rhTSH)] for radioactive iodine remnant ablation may be associated with differences in body mass at the time of the final follow-up. Design/Setting/Patients/Interventions: A retrospective review identified 153 patients with thyroid cancer who underwent total thyroidectomy at one major medical centre. Of the 153 patients, 143 also had radioactive iodine remnant ablation: 70 after THW and 73 after rhTSH. Main Outcome Measures: Change in weight and BMI at 1-2 and 3-5 years of follow-up points were examined. Annualized weight variation within the cohort was compared with agematched population controls expressed in kilogram/year. Results: Significant weight gain was noted for the full cohort after 3-5 years of follow-up as compared to baseline (76 ± 21 kg at baseline vs 79 ± 23 kg at 3-5 years of follow-up, P < 0.01), which represented a 3.2% increase. Female and male patients with thyroid cancer experienced 0.46 and 0.94 kg/year gain in weight, respectively, which is similar or somewhat higher than previously published age-matched population controls (ranging from 0.23 to 0.34 kg/year). When expressed as per cent change and comparing the final weight to the pre-operative baseline, the rhTSH group experienced approximately a 1.7% increase in weight compared with the 3.9% increase seen with THW patients (P = 0.02). When expressed as kg/year change, the rhTSH cohort had 0.34 kg/year change compared with the 0.64 kg/year change seen in the thyroid hormone withdrawal patients (P = 0.02). Conclusion: In otherwise, healthy patients with differentiated thyroid cancer, significant weight gain occurred during the 3-5 years of follow-up despite ongoing thyrotropin suppression. The data suggest that mild iatrogenic hyperthyroidism does not promote weight loss or prevent ageing-related weight gain. Greater weight gain was seen in patients prepared for radioactive remnant ablation with THW than with rhTSH. © 2012 Blackwell Publishing Ltd. |
| Journal Title: | Clinical Endocrinology |
| Volume: | 76 |
| Issue: | 4 |
| ISSN: | 0300-0664 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2012-04-01 |
| Start Page: | 582 |
| End Page: | 585 |
| Language: | English |
| DOI: | 10.1111/j.1365-2265.2011.04264.x |
| PROVIDER: | scopus |
| PUBMED: | 22004309 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 April 2012" - "CODEN: CLENA" - "Source: Scopus" |
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