Patterns of recurrence in 1988 FIGO stage IC endometrioid endometrial cancer Journal Article
| Authors: | Long, K. C.; Zhou, Q.; Hensley, M. L.; Alektiar, K. M.; Gomez, J.; Gardner, G. J.; Chi, D. S.; Barakat, R. R.; Abu-Rustum, N. R. |
| Article Title: | Patterns of recurrence in 1988 FIGO stage IC endometrioid endometrial cancer |
| Abstract: | Objectives: To evaluate patterns of recurrence in 1988 FIGO stage IC endometrioid endometrial adenocarcinoma. Methods: A prospectively maintained endometrial cancer database was utilized to identify all patients with stage IC endometrioid endometrial adenocarcinoma treated between 2/93 and 6/09. Patterns of recurrence and risk factors were analyzed. Results: One hundred thirty-four patients with stage IC endometrial cancer were identified. Median age was 66 years (range, 31-91 years). All patients were initially treated surgically, and 79% underwent comprehensive surgical staging with lymphadenectomy. Median number of lymph nodes removed was 18 (range, 1-45). Fifty-one patients (38%) had FIGO grade 1 tumors, 55 (41%) had grade 2 tumors, and 28 (21%) had grade 3 tumors. The majority of patients (91%) received adjuvant radiation therapy. With a median follow-up of 36 months (range, 0.6-141.4 months), 10 patients recurred. Of these, 2 (20%) were grade 1, 2 (20%) were grade 2, and 6 (60%) were grade 3. Nine (90%) of these recurrences had a distant component and 7 (70%) were fatal. Overall, the 3 year cumulative incidence failure rate for grade 1/2 tumors was 5.4%; for grade 3 tumors it was 28.9% (P < 0.001). Age, BMI, and lymphovascular invasion were not associated with an increased risk of recurrence. Conclusions: Patients with stage IC, grade 3 endometrial cancer had a significantly increased risk of recurrence (28.9%). All of these recurrences had a distant component and the majority were fatal. Further investigation into the addition of adjuvant systemic therapy in these high-risk patients is warranted. © 2012 Elsevier Inc. All rights reserved. |
| Keywords: | recurrence; 1988 figo stage ic endometrioid endometrial adenocarcinoma; patterns of recurrence |
| Journal Title: | Gynecologic Oncology |
| Volume: | 125 |
| Issue: | 1 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-04-01 |
| Start Page: | 99 |
| End Page: | 102 |
| Language: | English |
| DOI: | 10.1016/j.ygyno.2011.11.020 |
| PROVIDER: | scopus |
| PUBMED: | 22112609 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 April 2012" - "CODEN: GYNOA" - "Source: Scopus" |
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270Gardner -
629Barakat -
707Chi -
333Alektiar -
888Abu-Rustum -
254Zhou -
290Hensley -
247Long Roche -
6Gomez
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