Clinical and laboratory characteristics of Clostridium difficile infection in patients with discordant diagnostic test results Journal Article
| Authors: | Kaltsas, A.; Simon, M.; Unruh, L. H.; Son, C.; Wroblewski, D.; Musser, K. A.; Sepkowitz, K.; Babady, N. E.; Kamboj, M. |
| Article Title: | Clinical and laboratory characteristics of Clostridium difficile infection in patients with discordant diagnostic test results |
| Abstract: | The aim of this study was to compare the clinical and laboratory characteristics of Clostridium difficile infection (CDI) in patients with discordant test results for the cytotoxin assay (CYT) and PCR assays. A retrospective study from May to August 2008 and March to May 2010 was performed. CDI was diagnosed in 128 patients. PCR increased the yield of C. difficile cases by 2-fold compared to that of the CYT assay. Fifty-six cases (44%) were detected by PCR only (CYT negative). Forty-nine percent of patients with non-NAP1 strains were detected by PCR only, compared to 28% of those infected with NAP1 strains (P < 0.05). No significant differences were found in the clinical severity of illness and outcome among patients that tested positive for CDI by both tests (CYT and PCR) compared to those that tested positive by PCR only. Copyright © 2012, American Society for Microbiology. All Rights Reserved. |
| Keywords: | adolescent; adult; child; controlled study; aged; aged, 80 and over; child, preschool; middle aged; young adult; major clinical study; diarrhea; antineoplastic agent; sensitivity and specificity; polymerase chain reaction; disease association; clinical assessment; incidence; cohort analysis; hematopoietic stem cell transplantation; retrospective study; bacterial strain; abdominal pain; fever; length of stay; hospitalization; bacterial proteins; disease severity; laboratory test; nausea and vomiting; recurrent disease; sepsis; intermethod comparison; colitis; clostridium difficile infection; symptomatology; leukocyte count; clostridium difficile; false negative reactions; leukocytosis; feces; cross infection; molecular diagnostic techniques; cytotoxin; clostridium infections; septic shock; bacterial toxins; cytotoxin assay |
| Journal Title: | Journal of Clinical Microbiology |
| Volume: | 50 |
| Issue: | 4 |
| ISSN: | 0095-1137 |
| Publisher: | American Society for Microbiology |
| Date Published: | 2012-04-01 |
| Start Page: | 1303 |
| End Page: | 1307 |
| Language: | English |
| DOI: | 10.1128/jcm.05711-11 |
| PROVIDER: | scopus |
| PUBMED: | 22238444 |
| PMCID: | PMC3318505 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 April 2012" - "CODEN: JCMID" - "Source: Scopus" |
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