Peli: A family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance Journal Article
| Authors: | Jin, W.; Chang, M.; Sun, S. C. |
| Article Title: | Peli: A family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance |
| Abstract: | E3 ubiquitin ligases play a crucial role in regulating immune receptor signaling and modulating immune homeostasis and activation. One emerging family of such E3s is the Pelle-interacting (Peli) proteins, characterized by the presence of a cryptic forkhead-associated domain involved in substrate binding and an atypical RING domain mediating formation of both lysine (K) 63- and K48-linked polyubiquitin chains. A well-recognized function of Peli family members is participation in the signal transduction mediated by Toll-like receptors (TLRs) and IL-1 receptor. Recent gene targeting studies have provided important insights into the in vivo functions of Peli1 in the regulation of TLR signaling and inflammation. These studies have also extended the biological functions of Peli1 to the regulation of T-cell tolerance. Consistent with its immunoregulatory functions, Peli1 responds to different immune stimuli for its gene expression and catalytic activation. In this review, we discuss the recent progress, as well as the historical perspectives in the regulation and biological functions of Peli. © 2012 CSI and USTC. All rights reserved. |
| Keywords: | signal transduction; unclassified drug; review; nonhuman; protein domain; protein function; t lymphocyte; t-lymphocytes; animals; gene targeting; gene overexpression; transforming growth factor beta; protein protein interaction; interleukin 1beta; protein binding; drosophila; immunoglobulin enhancer binding protein; enzyme activation; enzyme activity; nuclear proteins; gene expression regulation; immunological tolerance; immune tolerance; enzyme phosphorylation; transcription regulation; ubiquitination; gamma interferon; receptors, interleukin-1; autoimmunity; immunomodulation; tumor necrosis factor receptor; ubiquitin protein ligase e3; sumoylation; forkhead transcription factor; ubiquitin-protein ligases; genetic conservation; t lymphocyte activation; toll like receptor; enzyme mechanism; toll-like receptors; tumor necrosis factor receptor associated factor 6; interleukin 1 receptor; tlr; interleukin 1 receptor associated kinase 1; peli; pellino; t-cell tolerance; nf-?b; interleukin 1 receptor associated kinase 4; pelle interacting protein |
| Journal Title: | Cellular & Molecular Immunology |
| Volume: | 9 |
| Issue: | 2 |
| ISSN: | 1672-7681 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2012-03-01 |
| Start Page: | 113 |
| End Page: | 122 |
| Language: | English |
| DOI: | 10.1038/cmi.2011.60 |
| PROVIDER: | scopus |
| PUBMED: | 22307041 |
| PMCID: | PMC4002811 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 April 2012" - "Source: Scopus" |
