A review of cancer in U.S. Hispanic populations Journal Article

Authors: Haile, R. W.; John, E. M.; Levine, A. J.; Cortessis, V. K.; Unger, J. B.; Gonzales, M.; Ziv, E.; Thompson, P.; Spruijt-Metz, D.; Tucker, K. L.; Bernstein, J. L.; Rohan, T. E.; Ho, G. Y. F.; Bondy, M. L.; Martínez, M. E.; Cook, L.; Stern, M. C.; Correa, M. C.; Wright, J.; Schwartz, S. J.; Baezconde-Garbanati, L.; Blinder, V.; Miranda, P.; Hayes, R.; Friedman-Jimenez, G.; Monroe, K. R.; Haiman, C. A.; Henderson, B. E.; Thomas, D. C.; Boffetta, P.
Article Title: A review of cancer in U.S. Hispanic populations
Abstract: There are compelling reasons to conduct studies of cancer in Hispanics, the fastest growing major demographic group in the United States (from 15% to 30% of the U.S. population by 2050). The genetically admixed Hispanic population coupled with secular trends in environmental exposures and lifestyle/ behavioral practices that are associated with immigration and acculturation offer opportunities for elucidating the effects of genetics, environment, and lifestyle on cancer risk and identifying novel risk factors. For example, traditional breast cancer risk factors explain less of the breast cancer risk in Hispanics than in non-Hispanic whites (NHW), and there is a substantially greater proportion of never-smokers with lung cancer in Hispanics than in NHW. Hispanics have higher incidence rates for cancers of the cervix, stomach, liver, and gall bladder than NHW. With respect to these cancers, there are intriguing patterns that warrant study (e.g., depending on country of origin, the five-fold difference in gastric cancer rates for Hispanic men but not Hispanic women). Also, despite a substantially higher incidence rate and increasing secular trend for liver cancer in Hispanics, there have been no studies of Hispanics reported to date. We review the literature and discuss study design options and features that should be considered in future studies. ©2012 AACR.
Keywords: review; cancer risk; united states; methodology; cancer incidence; neoplasm; colorectal cancer; biological marker; prostate specific antigen; heredity; breast cancer; genetic association; cancer screening; lung cancer; cancer mortality; risk assessment; prostate cancer; mammography; uterine cervix cancer; stomach cancer; behavior; liver cancer; sex difference; thyroid cancer; physical activity; high risk population; acute lymphocytic leukemia; environmental factor; gallbladder cancer; ethnic group; sigmoidoscopy; environmental exposure; cultural factor; occult blood; caucasian; lifestyle; hispanic; digital rectal examination; papanicolaou test; metabolomics; nutritional assessment; immigration
Journal Title: Cancer Prevention Research
Volume: 5
Issue: 2
ISSN: 1940-6207
Publisher: American Association for Cancer Research  
Date Published: 2012-02-01
Start Page: 150
End Page: 163
Language: English
DOI: 10.1158/1940-6207.capr-11-0447
PROVIDER: scopus
PUBMED: 22307564
PMCID: PMC5815320
Notes: --- - "Export Date: 2 April 2012" - "Source: Scopus"
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MSK Authors
  1. Victoria Susana Blinder
    45 Blinder
  2. Jonine L Bernstein
    104 Bernstein