The androgen receptor in breast cancer: Biology and treatment considerations Journal Article
| Authors: | Gucalp, A.; Traina, T. A. |
| Article Title: | The androgen receptor in breast cancer: Biology and treatment considerations |
| Abstract: | The androgen receptor (AR) is expressed in 70-90% of invasive breast cancers. Despite the ubiquitous expression of AR in both primary and metastatic breast cancers, the clinical significance of this hormone receptor as a prognostic/predictive marker and its functional role in tumorigenesis remains poorly understood. This review summarizes the recent progress made in understanding the role of the AR as a prognostic/predictive marker in breast cancer and the underlying mechanisms by which the androgen-signaling pathway may be involved in breast cancer pathogenesis. In addition, this review examines the available clinical data for the use of androgen-blocking agents in the treatment of breast cancer and explores the ongoing development of newer AR-targeted agents in this setting. © 2011 Springer Science+Business Media, LLC. |
| Keywords: | breast cancer; androgen receptor |
| Journal Title: | Current Breast Cancer Reports |
| Volume: | 4 |
| Issue: | 1 |
| ISSN: | 1943-4588 |
| Publisher: | Springer |
| Date Published: | 2012-01-01 |
| Start Page: | 56 |
| End Page: | 65 |
| Language: | English |
| DOI: | 10.1007/s12609-011-0059-z |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 April 2012" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work