Genetic and molecular characterization of uveal melanoma cell lines Journal Article

   


Authors: Griewank, K. G.; Yu, X.; Khalili, J.; Sozen, M. M.; Stempke-Hale, K.; Bernatchez, C.; Wardell, S.; Bastian, B. C.; Woodman, S. E.
Article Title: Genetic and molecular characterization of uveal melanoma cell lines
Abstract: The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal melanoma provides an opportunity to better understand the pathogenesis of this melanoma subtype and to develop rational therapeutics to target the cellular effects mediated by these mutations. Cell lines from uveal melanoma tumors are an essential tool for these types of analyses. We report the mutation status of relevant melanoma genes, expression levels of proteins of interest, and DNA fingerprinting of a panel of uveal melanoma cell lines used in the research community. Published 2012. This article is a US Government work and is in the public domain in the USA.
Keywords: protein kinase b; controlled study; gene mutation; human cell; mutation; genetic analysis; melanoma; gene expression; tumor markers, biological; genotype; cell line, tumor; phosphatidylinositol 3 kinase; cancer genetics; gene expression regulation, neoplastic; messenger rna; rna, messenger; melanoma cell; dna fingerprinting; protein s 100; monophenol monooxygenase; uvea melanoma; uveal neoplasms; tyrosinase related protein 1; b raf kinase; cyclin dependent kinase 4; genes, neoplasm; gna11; gnaq; uveal melanoma; guanine nucleotide binding protein alpha subunit
Journal Title: Pigment Cell & Melanoma Research
Volume: 25
Issue: 2
ISSN: 1755-1471
Publisher: Wiley Blackwell  
Date Published: 2012-03-01
Start Page: 182
End Page: 187
Language: English
DOI: 10.1111/j.1755-148X.2012.00971.x
PROVIDER: scopus
PMCID: PMC3288394
PUBMED: 22236444
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84857444671&partnerID=40&md5=513cc1e7acec2356c5d31cd24ffcfb25
Notes: --- - "Export Date: 2 April 2012" - "Source: Scopus"
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MSK Authors
  1. Mustafa Mert Sozen
    2 Sozen
  2. Klaus Georg Griewank
    16 Griewank
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