Bone scan index: A quantitative treatment response biomarker for castration-resistant metastatic prostate cancer Journal Article
| Authors: | Dennis, E. R.; Jia, X.; Mezheritskiy, I. S.; Stephenson, R. D.; Schoder, H.; Fox, J. J.; Heller, G.; Scher, H. I.; Larson, S. M.; Morris, M. J. |
| Article Title: | Bone scan index: A quantitative treatment response biomarker for castration-resistant metastatic prostate cancer |
| Abstract: | Purpose: There is currently no imaging biomarker for metastatic prostate cancer. The bone scan index (BSI) is a promising candidate, being a reproducible, quantitative expression of tumor burden seen on bone scintigraphy. Prior studies have shown the prognostic value of a baseline BSI. This study tested whether treatment-related changes in BSI are prognostic for survival and compared BSI to prostate-specific antigen (PSA) as an outcome measure. Patients and Methods: We retrospectively examined serial bone scans from patients with castration-resistant metastatic prostate cancer (CRMPC) enrolled in four clinical trials. We calculated BSI at baseline and at 3 and 6 months on treatment and performed univariate and bivariate analyses of PSA, BSI, and survival. Results: Eighty-eight patients were scanned, 81 of whom have died. In the univariate analysis, the log percent change in BSI from baseline to 3 and 6 months on treatment prognosticated for survival (hazard ratio [HR], 2.44; P = .0089 and HR, 2.54; P < .001, respectively). A doubling in BSI resulted in a 1.9-fold increase in risk of death. Log percent change in PSA at 6 months on treatment was also associated with survival (HR, 1.298; P = .013). In the bivariate analysis, change in BSI while adjusting for PSA was prognostic at 3 and 6 months on treatment (HR, 2.368; P = .012 and HR, 2.226; P = .002, respectively), but while adjusting for BSI, PSA was not prognostic. Conclusion: These data furnish early evidence that on-treatment changes in BSI are a response indicator and support further exploration of bone scintigraphy as an imaging biomarker in CRMPC. © 2012 by American Society of Clinical Oncology. |
| Keywords: | adult; cancer survival; treatment response; aged; major clinical study; bone metastasis; prostate specific antigen; tumor volume; mathematical model; bone scintiscanning; castration resistant prostate cancer; bone scan index; musculoskeletal system parameters |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 30 |
| Issue: | 5 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2012-02-10 |
| Start Page: | 519 |
| End Page: | 524 |
| Language: | English |
| DOI: | 10.1200/jco.2011.36.5791 |
| PROVIDER: | scopus |
| PMCID: | PMC3295554 |
| PUBMED: | 22231045 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 2 April 2012" - "CODEN: JCOND" - "Source: Scopus" |
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