Accelerated hematopoietic toxicity by high energy (56)Fe radiation Journal Article
| Authors: | Datta, K.; Suman, S.; Trani, D.; Doiron, K.; Rotolo, J. A.; Kallakury, B. V. S.; Kolesnick, R.; Cole, M. F.; Fornace, A. J. Jr |
| Article Title: | Accelerated hematopoietic toxicity by high energy (56)Fe radiation |
| Abstract: | Purpose: There is little information on the relative toxicity of highly charged (Z) high-energy (HZE) radiation in animal models compared to γ or X-rays, and the general assumption based on in vitro studies has been that acute toxicity is substantially greater. Methods: C57BL/6J mice were irradiated with 56Fe ions (1 GeV/nucleon), and acute (within 30 d) toxicity compared to that of γ rays or protons (1 GeV). To assess relative hematopoietic and gastrointestinal toxicity, the effects of 56Fe ions were compared to γ rays using complete blood count (CBC), bone marrow granulocyte- macrophage colony forming unit (GM-CFU), terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay for apoptosis in bone marrow, and intestinal crypt survival. Results: Although onset was more rapid, 56Fe ions were only slightly more toxic than γ rays or protons with lethal dose (LD)50/30 (a radiation dose at which 50% lethality occurs at 30-day) values of 5.8, 7.25, and 6.8 Gy, respectively, with relative biologic effectiveness for 56Fe ions of 1.25 and 1.06 for protons. Conclusions: 56Fe radiation caused accelerated and more severe hematopoietic toxicity. Early mortality correlated with more profound leukopenia and subsequent sepsis. Results indicate that there is selective enhanced toxicity to bone marrow progenitor cells, which are typically resistant to γ rays, and bone marrow stem cells, because intestinal crypt cells did not show increased HZE toxicity. © 2012 Informa UK, Ltd. |
| Keywords: | controlled study; mortality; nonhuman; radiation dose; animal cell; mouse; animals; mice; animal tissue; cell survival; mus; apoptosis; bone marrow; radiation; blood toxicity; leukopenia; animal experiment; cell assay; mice, inbred c57bl; time factors; animalia; gastrointestinal toxicity; irradiation; iron; sepsis; hematopoiesis; protons; bacteremia; bone marrow cell; hematopoietic stem cell; relative biological effectiveness; blood cell count; c57bl 6 mouse; gastrointestinal tract; relative biologic effectiveness; nick end labeling; proton radiation; colony forming unit gm; whole-body irradiation; intestine crypt; gamma radiation; gamma rays; crypt cell; linear energy transfer; heavy ions; heavy ion radiation; hematopoietic toxicity; myeloid toxicity; space radiation; ld 50 |
| Journal Title: | International Journal of Radiation Biology |
| Volume: | 88 |
| Issue: | 3 |
| ISSN: | 0955-3002 |
| Publisher: | Taylor & Francis Group Ltd. |
| Date Published: | 2012-03-01 |
| Start Page: | 213 |
| End Page: | 222 |
| Language: | English |
| DOI: | 10.3109/09553002.2012.639434 |
| PROVIDER: | scopus |
| PUBMED: | 22077279 |
| PMCID: | PMC3580183 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 April 2012" - "CODEN: IJRBA" - "Source: Scopus" |
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