RNA-Puzzles: A CASP-like evaluation of RNA three-dimensional structure prediction Journal Article
| Authors: | Cruz, J. A.; Blanchet, M. F.; Boniecki, M.; Bujnicki, J. M.; Chen, S. J.; Cao, S.; Das, R.; Ding, F.; Dokholyan, N. V.; Flores, S. C.; Huang, L.; Lavender, C. A.; Lisi, V.; Major, F.; Mikolajczak, K.; Patel, D. J.; Philips, A.; Puton, T.; Santalucia, J.; Sijenyi, F.; Hermann, T.; Rother, K.; Rother, M.; Serganov, A.; Skorupski, M.; Soltysinski, T.; Sripakdeevong, P.; Tuszynska, I.; Weeks, K. M.; Waldsich, C.; Wildauer, M.; Leontis, N. B.; Westhof, E. |
| Article Title: | RNA-Puzzles: A CASP-like evaluation of RNA three-dimensional structure prediction |
| Abstract: | We report the results of a first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles. The goals are to assess the leading edge of RNA structure prediction techniques; compare existing methods and tools; and evaluate their relative strengths, weaknesses, and limitations in terms of sequence length and structural complexity. The results should give potential users insight into the suitability of available methods for different applications and facilitate efforts in the RNA structure prediction community in ongoing efforts to improve prediction tools. We also report the creation of an automated evaluation pipeline to facilitate the analysis of future RNA structure prediction exercises. Published by Cold Spring Harbor Laboratory Press. Copyright © 2012 RNA Society. |
| Keywords: | controlled study; sequence analysis; rna; molecular sequence data; base sequence; base pairing; models, molecular; dimerization; nucleic acid conformation; protein folding; rna structure; bioinformatics; rna sequence; structure; rna analysis; 3d prediction; force fields |
| Journal Title: | RNA |
| Volume: | 18 |
| Issue: | 4 |
| ISSN: | 1355-8382 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2012-04-01 |
| Start Page: | 610 |
| End Page: | 625 |
| Language: | English |
| DOI: | 10.1261/rna.031054.111 |
| PROVIDER: | scopus |
| PUBMED: | 22361291 |
| PMCID: | PMC3312550 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 2 April 2012" - "CODEN: RNARF" - "Source: Scopus" |
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