Cutaneous T-cell lymphomas: A review of new discoveries and treatments Journal Article
| Authors: | Bloom, T.; Kuzel, T. M.; Querfeld, C.; Guitart, J.; Rosen, S. T. |
| Article Title: | Cutaneous T-cell lymphomas: A review of new discoveries and treatments |
| Abstract: | Opinion statement: Treatment regimens of patients with CTCL vary widely based on clinician preference and patient tolerance. Skin directed therapies are recommended for patients with early stage IA and IB MF, with combinations used in refractory cases. While no regimen has been proven to prolong survival in advanced stages, immunomodulatory regimens should be used initially to reduce the need for cytotoxic therapies. In more advanced stages of disease, treatment efforts should strive for palliation and improvement of quality of life. With many new therapies and strategies on the horizon, the future looks promising for CTCL patients. Unfortunately, other than allogeneic HCT, there are no potential curative therapies for CTCL. Clinical trials are currently underway to identify new therapies to improve quality of life for patients, and researchers are hard at work to identify novel pathways and genes for prognostication and as targets for therapies. Importantly, collaborative clinical trials to enhance rates of accrual need to be conducted, and improved interpretation of data via standardizing end points and response criteria should be an emphasis. Recently, the International Society for Cutaneous Lymphomas (ISCL), the United States Cutaneous Lymphoma Consortium (USCLC), and the Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer (EORTC) met to develop consensus guidelines to facilitate collaboration on clinical trials. These proposed guidelines consist of: recommendations for standardizing general protocol design; a scoring system for assessing tumor burden in skin, lymph nodes, blood, and viscera; definition of response in skin, nodes, blood, and viscera; a composite global response score; and a definition of end points. Although these guidelines were generated by consensus panels, they have not been prospectively or retrospectively validated through analysis of large patient cohorts. © 2012 Springer Science+Business Media, LLC. |
| Keywords: | cancer chemotherapy; leukemia; overall survival; fludarabine; lenalidomide; prednisone; drug tolerability; fatigue; review; doxorubicin; placebo; advanced cancer; cancer combination chemotherapy; diarrhea; drug dose comparison; drug efficacy; drug withdrawal; alpha interferon; gemcitabine; disease free survival; treatment; cytarabine; methotrexate; cancer staging; cancer palliative therapy; unindexed drug; progression free survival; quality of life; bortezomib; infection; mantle cell lymphoma; multiple cycle treatment; multiple myeloma; anemia; tumor volume; gastrointestinal symptom; stomatitis; fas antigen; notch receptor; cyclophosphamide; vincristine; clinical protocol; herpes simplex; herpes zoster; practice guideline; carmustine; chlormethine; asthenia; drug dose escalation; drug hypersensitivity; pruritus; cancer genetics; chromosome aberration; malaise; cancer regression; cutaneous t cell lymphoma; hematologic malignancy; scoring system; vorinostat; allogeneic hematopoietic stem cell transplantation; flu like syndrome; hypothyroidism; tumor growth; immune deficiency; corticosteroid; drug dose increase; autoimmune disease; bacterial infection; t cell leukemia; romidepsin; cytopenia; leg edema; mycosis fungoides; cytomegalovirus infection; mycosis; autologous hematopoietic stem cell transplantation; pralatrexate; hypertriglyceridemia; enzastaurin; alemtuzumab; vascular disease; opportunistic infection; clobetasol; programmed death 1 receptor; adrenal insufficiency; retinoids; tazarotene; puva; skin burning sensation; denileukin diftitox; sezary syndrome; etretin; bexarotene; psoralen; pneumocystosis; vascular leak syndrome; cutaneous cd30+ t-cell lymphoproliferative disorders; cutaneous t-cell lymphomas (ctlc); central hypothyroidism; total skin electron therapy |
| Journal Title: | Current Treatment Options in Oncology |
| Volume: | 13 |
| Issue: | 1 |
| ISSN: | 1527-2729 |
| Publisher: | Springer |
| Date Published: | 2012-03-01 |
| Start Page: | 102 |
| End Page: | 121 |
| Language: | English |
| DOI: | 10.1007/s11864-011-0179-8 |
| PROVIDER: | scopus |
| PUBMED: | 22311555 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 April 2012" - "CODEN: CTOOB" - "Source: Scopus" |
