Intra-arterial chemotherapy for retinoblastoma in eyes with vitreous and/or subretinal seeding: 2-Year results Journal Article


Authors: Abramson, D. H.; Marr, B. P.; Dunkel, I. J.; Brodie, S.; Zabor, E. C.; Driscoll, S. J.; Gobin, Y. P.
Article Title: Intra-arterial chemotherapy for retinoblastoma in eyes with vitreous and/or subretinal seeding: 2-Year results
Abstract: Background/aims: To review the effectiveness of intraarterial chemotherapy for advanced intra-ocular retinoblastoma with vitreous and/or subretinal seeds in naive (untreated) and previously treated eyes. Methods: Retrospective study, approved by the institutional review board, of 76 eyes of 67 patients with retinoblastoma with subretinal and/or vitreous seeding treated with intra-arterial chemotherapy at Memorial Sloan-Kettering Cancer Center between May 2006 and August 2010. Results: Despite advanced intraocular disease with seeding, the majority (56/76) of eyes were saved; 20/76 eyes were enucleated. Among treatment-naive eyes, the 2-year probability of ocular salvage was 83% (95% CI 27% to 97%) for eyes with subretinal seeding only, 64% (95% CI 24% to 87%) for eyes with vitreous seeding only, and 80% (95% CI 40% to 95%) for eyes with both. Among eyes that received previous treatment and had progressed, the 2-year probability of ocular salvage was 50% (95% CI 15% to 78%) for eyes with only subretinal seeding, 76% (95% CI 48% to 91%) for eyes with vitreous seeding only, and 54% (95% CI 20% to 79%) for eyes with both. Nine of 29 naive eyes (31%) were cured with intra-arterial (super-selective ophthalmic artery infusion of chemotherapy) chemotherapy alone. Conclusion: Unlike radiation or systemic chemotherapy, intra-arterial chemotherapy can usually prevent the need for enucleation in naive eyes with advanced intraocular retinoblastoma with seeding - especially if the seeding is subretinal. Treatment appears to be less effective in previously treated eyes when subretinal seeding is present (50% at 2 years), but may be more effective in eyes that failed to respond to previous systemic chemotherapy and have only vitreous seeding.
Journal Title: British Journal of Ophthalmology
Volume: 96
Issue: 4
ISSN: 0007-1161
Publisher: BMJ Publishing Group Ltd.  
Date Published: 2012-04-01
Start Page: 499
End Page: 502
Language: English
DOI: 10.1136/bjophthalmol-2011-300498
PROVIDER: scopus
PUBMED: 22053101
DOI/URL:
Notes: --- - "Export Date: 2 April 2012" - "CODEN: BJOPA" - "Source: Scopus"
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MSK Authors
  1. Brian Marr
    108 Marr
  2. Ira J Dunkel
    255 Dunkel
  3. David H Abramson
    255 Abramson
  4. Emily Craig Zabor
    131 Zabor