Conditions comorbid with chronic fatigue in a population-based sample Journal Article
| Authors: | Dansie, E. J.; Furberg, H.; Afari, N.; Buchwald, D.; Edwards, K.; Goldberg, J.; Schur, E.; Sullivan, P. F. |
| Article Title: | Conditions comorbid with chronic fatigue in a population-based sample |
| Abstract: | Background: Chronic fatigue syndrome (CFS) has been found to be comorbid with various medical conditions in clinical samples, but little research has investigated CFS comorbidity in population-based samples. Objective: This study investigated conditions concurrent with a CFS-like illness among twins in the population-based Mid-Atlantic Twin Registiy (MATR), including chronic widespread pain (CWP), irritable bowel syndrome (IBS), and major depressive disorder (MDD). Method: A survey was mailed to participants in the MATR in 1999. Generalized estimating equations were used to estimate odds ratios to assess associations between CFS-like illness and each comorbid condition. Results: A total of 4590 completed surveys were collected. Most participants were female (86.3%); mean age was 44.7 years. Among participants with a CFS-like illness, lifetime prevalences of CWP, IBS, and MDD were 41%, 16%, and 57% respectively. Participants reporting at least one of the three comorbid conditions were about 14 times more likely to have CFS-like illness than those without GYP, IBS, or MDD (95% confidence interval 8.1%-21.3%). Only MDD showed a temporal pattern of presentation during the same year as diagnosis of CFS-like illness. Age, gender, body mass index, age at illness onset, exercise level, self-reported health status, fatigue symptoms, and personality measures did not differ between those reporting CFS-like illness with and without comorbidity. Conclusion: These results support findings in clinically based samples that CFS-like illness is frequently cormorbid with CWP, IBS, and/or MDD. We found no evidence that CFS-like illnesses with comorbidities are clinically distinct from those without comorbidities. (Psychosomatics 2012; 53:44-50) |
| Keywords: | prevalence; depression; features; disorders; symptoms; functional somatic syndromes; pilot swedish twin; ascertained; subsamples; affective-illness; fibromyalgia |
| Journal Title: | Psychosomatics |
| Volume: | 53 |
| Issue: | 1 |
| ISSN: | 0033-3182 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2012-01-01 |
| Start Page: | 44 |
| End Page: | 50 |
| Language: | English |
| ACCESSION: | WOS:000299585700006 |
| PROVIDER: | wos |
| PMCID: | PMC3254018 |
| PUBMED: | 22221720 |
| DOI: | 10.1016/j.psym.2011.04.001 |
| Notes: | --- - Article - "Source: Wos" |
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